UniProt functional annotation for Q27974

UniProt code: Q27974.

Organism: Bos taurus (Bovine).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
 
Function: Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity).
 
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Subunit: Interacts with HSPA8/HSC70. Interacts with clathrin heavy chains.
Tissue specificity: Brain.
Ptm: The N-terminus is blocked.
Ptm: Target for coat-associated casein kinase II in vitro.
Similarity: Contains 1 C2 tensin-type domain.
Similarity: Contains 1 J domain.
Similarity: Contains 1 phosphatase tensin-type domain.

Annotations taken from UniProtKB at the EBI.