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PDBsum entry 2qqq
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Immune system
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PDB id
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2qqq
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References listed in PDB file
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Key reference
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Title
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A bony fish immunological receptor of the nitr multigene family mediates allogeneic recognition.
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Authors
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J.P.Cannon,
R.N.Haire,
A.T.Magis,
D.D.Eason,
K.N.Winfrey,
J.A.Hernandez prada,
K.M.Bailey,
J.Jakoncic,
G.W.Litman,
D.A.Ostrov.
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Ref.
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Immunity, 2008,
29,
228-237.
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PubMed id
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Abstract
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Novel immune-type receptors (NITRs) comprise an exceptionally large, diversified
family of activating and inhibitory receptors that has been identified in bony
fish. Here, we characterized the structure of an activating NITR that is
expressed by a cytotoxic natural killer (NK)-like cell line and that
specifically binds an allogeneic B cell target. A single amino acid residue
within the NITR immunoglobulin variable (V)-type domain accounts for specificity
of the interaction. Structures solved by X-ray crystallography revealed that the
V-type domains of NITRs form homodimers resembling rearranging antigen-binding
receptor heterodimers. CDR1 elements of both subunits of NITR dimers form
ligand-binding surfaces that determine specificity for the nonself target. In
the evolution of immune function, it appears that a specific NK type of innate
recognition may be mediated by a complex germline multigene family of V
structures resembling those that are somatically diversified in adaptive
immunological responses.
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