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UniProt functional annotation for O60462 | ||
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| UniProt code: O60462. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. |
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| Function: | |
(Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells. {ECO:0000269|PubMed:30057110}. |
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| Subunit: | |
Heterodimer with NRP1. Binds PLXNB1. {ECO:0000269|PubMed:17989695}. |
| Subunit: | |
(Microbial infection) Interacts with human cytomegalovirus proteins gL, UL128, UL130 and UL131A. {ECO:0000269|PubMed:30057110}. |
| Subcellular location: | |
Membrane {ECO:0000269|PubMed:11112349}; Single- pass type I membrane protein {ECO:0000269|PubMed:11112349}. |
| Subcellular location: | |
[Isoform s9]: Secreted {ECO:0000269|PubMed:11112349}. |
| Domain: | |
The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding. |
| Similarity: | |
Belongs to the neuropilin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.