UniProt functional annotation for P15806



	UniProt functional annotation for P15806

UniProt code: P15806.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (PubMed:15226298, PubMed:18214987). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (PubMed:18214987). Together with TCF15, required for the mesenchymal to epithelial transition (PubMed:11309385, PubMed:15226298). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (PubMed:15226298, PubMed:18214987). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (By similarity). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (PubMed:2181401). {ECO:0000250|UniProtKB:P15923, ECO:0000269|PubMed:11309385, ECO:0000269|PubMed:15226298, ECO:0000269|PubMed:18214987, ECO:0000269|PubMed:2181401}.

Subunit: Homodimer (PubMed:12196028). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein (PubMed:15226298). Forms a heterodimer with TWIST1 and TWIST2 (PubMed:7589808, PubMed:23395635). Forms a heterodimer with NEUROD1; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E- box element (PubMed:23395635, PubMed:18069799). Forms a heterodimer with TCF15; the heterodimer binds E-box element (PubMed:15226298, PubMed:23395635). Forms a heterodimer with MYOG; heterodimerization enhances MYOG DNA-binding and transcriptional activities (PubMed:12196028). Forms a heterodimer with ATOH8; repress transcription of TCF3 and TCF3-NEUROG3 dimer-induced transactivation of E box-dependent promoters (PubMed:23938248). Component of a nuclear TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 (PubMed:16407974). Interacts with NEUROD2 (PubMed:18214987). Interacts with EP300 (By similarity). Interacts with PTF1A, TGFB1I1 and UBE2I (PubMed:9409784, PubMed:11318877, PubMed:16291758). Interacts with BHLHA9 (By similarity). {ECO:0000250|UniProtKB:P15923, ECO:0000269|PubMed:11318877, ECO:0000269|PubMed:12196028, ECO:0000269|PubMed:15226298, ECO:0000269|PubMed:16291758, ECO:0000269|PubMed:16407974, ECO:0000269|PubMed:18069799, ECO:0000269|PubMed:18214987, ECO:0000269|PubMed:23395635, ECO:0000269|PubMed:23938248, ECO:0000269|PubMed:7589808, ECO:0000269|PubMed:9409784}.

Subunit: [Isoform E12]: Interacts with RALGAPA1 (PubMed:12200424). Interacts with FIGLA (By similarity). {ECO:0000250|UniProtKB:P15923, ECO:0000269|PubMed:12200424}.

Subcellular location: Nucleus {ECO:0000269|PubMed:12200424}.

Developmental stage: Expressed during the development of the nervous system. {ECO:0000269|PubMed:18214987}.

Ptm: Phosphorylated following NGF stimulation. {ECO:0000250}.

Disruption phenotype: Mice are smaller than their wild-type littermates and fail to thrive 14 days after birth. {ECO:0000269|PubMed:18214987}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (PubMed:15226298, PubMed:18214987). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (PubMed:18214987). Together with TCF15, required for the mesenchymal to epithelial transition (PubMed:11309385, PubMed:15226298). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (PubMed:15226298, PubMed:18214987). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (By similarity). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (PubMed:2181401). {ECO:0000250\|UniProtKB:P15923, ECO:0000269\|PubMed:11309385, ECO:0000269\|PubMed:15226298, ECO:0000269\|PubMed:18214987, ECO:0000269\|PubMed:2181401}.


Subunit:		Homodimer (PubMed:12196028). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein (PubMed:15226298). Forms a heterodimer with TWIST1 and TWIST2 (PubMed:7589808, PubMed:23395635). Forms a heterodimer with NEUROD1; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E- box element (PubMed:23395635, PubMed:18069799). Forms a heterodimer with TCF15; the heterodimer binds E-box element (PubMed:15226298, PubMed:23395635). Forms a heterodimer with MYOG; heterodimerization enhances MYOG DNA-binding and transcriptional activities (PubMed:12196028). Forms a heterodimer with ATOH8; repress transcription of TCF3 and TCF3-NEUROG3 dimer-induced transactivation of E box-dependent promoters (PubMed:23938248). Component of a nuclear TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 (PubMed:16407974). Interacts with NEUROD2 (PubMed:18214987). Interacts with EP300 (By similarity). Interacts with PTF1A, TGFB1I1 and UBE2I (PubMed:9409784, PubMed:11318877, PubMed:16291758). Interacts with BHLHA9 (By similarity). {ECO:0000250\|UniProtKB:P15923, ECO:0000269\|PubMed:11318877, ECO:0000269\|PubMed:12196028, ECO:0000269\|PubMed:15226298, ECO:0000269\|PubMed:16291758, ECO:0000269\|PubMed:16407974, ECO:0000269\|PubMed:18069799, ECO:0000269\|PubMed:18214987, ECO:0000269\|PubMed:23395635, ECO:0000269\|PubMed:23938248, ECO:0000269\|PubMed:7589808, ECO:0000269\|PubMed:9409784}.
Subunit:		[Isoform E12]: Interacts with RALGAPA1 (PubMed:12200424). Interacts with FIGLA (By similarity). {ECO:0000250\|UniProtKB:P15923, ECO:0000269\|PubMed:12200424}.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:12200424}.
Developmental stage:		Expressed during the development of the nervous system. {ECO:0000269\|PubMed:18214987}.
Ptm:		Phosphorylated following NGF stimulation. {ECO:0000250}.
Disruption phenotype:		Mice are smaller than their wild-type littermates and fail to thrive 14 days after birth. {ECO:0000269\|PubMed:18214987}.