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PDBsum entry 2qiq
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Viral protein
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PDB id
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2qiq
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References listed in PDB file
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Key reference
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Title
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Structure-Based design, Synthesis, And biological evaluation of peptidomimetic sars-Cov 3clpro inhibitors.
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Authors
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A.K.Ghosh,
K.Xi,
V.Grum-Tokars,
X.Xu,
K.Ratia,
W.Fu,
K.V.Houser,
S.C.Baker,
M.E.Johnson,
A.D.Mesecar.
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Ref.
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Bioorg Med Chem Lett, 2007,
17,
5876-5880.
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PubMed id
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Abstract
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Structure-based design, synthesis, and biological evaluation of a series of
peptidomimetic severe acute respiratory syndrome-coronavirus chymotrypsin-like
protease inhibitors are described. These inhibitors were designed and
synthesized based upon our X-ray crystal structure of inhibitor 1 bound to
SARS-CoV 3CLpro. Incorporation of Boc-Ser as the P(4)-ligand resulted in
enhanced SARS-CoV 3CLpro inhibitory activity. Structural analysis of the
inhibitor-bound X-ray structure revealed high binding affinity toward the enzyme.
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