PDBsum entry 2qcj

Hydrolase

PDB id: 2qcj

Contents

Protein chain

280 a.a. *

Waters ×23

* Residue conservation analysis

PDB id:

2qcj

Name:

Hydrolase

Title:

Native structure of lyp

Structure:

Tyrosine-protein phosphatase non-receptor type 22. Chain: a, b. Fragment: catalytic domain. Synonym: hematopoietic cell protein-tyrosine phosphatase 70z-pep, lymphoid phosphatase, lyp. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn22, ptpn8. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.

Resolution:

3.00Å R-factor: 0.284 R-free: 0.307

Authors:

J.P.Sun,X.Yu,Z.Y.Zhang

Key ref:

X.Yu et al. Crystal structure of lyp and its complex with a selective inhibitor. To be published, .

Date:

19-Jun-07 Release date: 20-Nov-07

Protein chains

Q9Y2R2  (PTN22_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 22 from Homo sapiens

Seq: 807 a.a.

Struc: 280 a.a.

Enzyme reactions

• Enzyme class: E.C.3.1.3.48 - protein-tyrosine-phosphatase.
• Reaction: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site