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UniProt functional annotation for Q97WM8 | ||
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| UniProt code: Q97WM8. |
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| Organism: | |
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus). |
| Taxonomy: | |
Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Saccharolobus. |
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| Function: | |
Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds to DNA, with a preference for molecules that contain a bubble, a fork, or a tail. Inhibits the binding of the MCM helicase to the origin DNA and inhibits its DNA helicase activity. Also regulates the DNA polymerase and the nuclease activities of PolB1. Inhibits the DNA- binding activity of Cdc6-1 and Cdc6-2. {ECO:0000255|HAMAP- Rule:MF_01407, ECO:0000269|PubMed:16179962, ECO:0000269|PubMed:17673179, ECO:0000269|PubMed:17825793, ECO:0000269|PubMed:19416914}. |
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| Subunit: | |
Monomer. Interacts with Cdc6-1, Cdc6-2, MCM and PolB1. {ECO:0000269|PubMed:16179962, ECO:0000269|PubMed:17673179, ECO:0000269|PubMed:17761879, ECO:0000269|PubMed:17825793, ECO:0000269|PubMed:19416914}. |
| Similarity: | |
Belongs to the CDC6/cdc18 family. {ECO:0000255|HAMAP- Rule:MF_01407}. |
Annotations taken from UniProtKB at the EBI.