PDBsum entry 2q0n

Transferase

PDB id: 2q0n

Contents

Protein chains

294 a.a. *

11 a.a. *

Ligands

SO4

EDO ×8

Waters ×256

* Residue conservation analysis

PDB id:

2q0n

Name:

Transferase

Title:

Structure of human p21 activating kinase 4 (pak4) in complex with a consensus peptide

Structure:

Serine/threonine-protein kinase pak 4. Chain: a. Fragment: kinase domain, residues 291-591. Synonym: p21-activated kinase 4, pak-4. Engineered: yes. Synthetic peptide. Chain: b. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pak4, kiaa1142. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide

Resolution:

1.75Å R-factor: 0.185 R-free: 0.228

Authors:

P.Filippakopoulos,J.Eswaran,A.Turnbull,E.Papagrigoriou,A.W.Pike,F.Von Delft,M.Sundstrom,A.Edwards,C.H.Arrowsmith,J.Weigelt,S.Knapp, Structural Genomics Consortium (Sgc)

Key ref:

P.Filippakopoulos et al. Structure of human p21 activating kinase 4 (pak4) in complex with a consensus peptide.. To be published, .

Date:

22-May-07 Release date: 26-Jun-07

Protein chain

O96013  (PAK4_HUMAN) -  Serine/threonine-protein kinase PAK 4 from Homo sapiens

Seq: 591 a.a.

Struc: 294 a.a.

Protein chain

No UniProt id for this chain

Struc: 11 a.a.

Enzyme reactions

• Enzyme class: Chain A: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site