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UniProt functional annotation for Q8IZ41 | ||
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| UniProt code: Q8IZ41. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Binds predominantly GDP, and also GTP (PubMed:17448446). Acts as a dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules (PubMed:30814157). {ECO:0000269|PubMed:17448446, ECO:0000269|PubMed:30814157}. |
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| Subunit: | |
Homodimer (PubMed:17448446). Interacts with the dynein- dynactin complex (PubMed:30814157). {ECO:0000269|PubMed:17448446, ECO:0000269|PubMed:30814157}. |
| Subcellular location: | |
Cytoplasm, perinuclear region {ECO:0000269|PubMed:17448446}. |
| Tissue specificity: | |
Down-regulated in cutaneous melanoma cells but not in breast cancer cells. {ECO:0000269|PubMed:16174859}. |
| Similarity: | |
Belongs to the small GTPase superfamily. Rab family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.