UniProt functional annotation for P0A2D5



	UniProt functional annotation for P0A2D5

UniProt code: P0A2D5.

Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).

Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella.

Function: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. In its active (phosphorylated or acetylated) form, CheY exhibits enhanced binding to a switch component, FliM, at the flagellar motor which induces a change from counterclockwise to clockwise flagellar rotation. Shows autophosphatase activity which is enhanced by CheZ.

Cofactor: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;

Subunit: Interacts (phosphorylated CheY) with CheZ (via C-terminus). {ECO:0000269|PubMed:16674976, ECO:0000269|PubMed:18083806, ECO:0000269|PubMed:9837737}.

Subcellular location: Cytoplasm.

Ptm: Phosphorylated by CheA or acetylated by acetyl-CoA synthetase, depending on which acetate metabolism pathway is available (By similarity). Dephosphorylated (inactivated) by CheZ. {ECO:0000250, ECO:0000269|PubMed:1902474, ECO:0000269|PubMed:3280143}.

Annotations taken from UniProtKB at the EBI.


Organism:		Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
Taxonomy:		Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella.



Function:		Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. In its active (phosphorylated or acetylated) form, CheY exhibits enhanced binding to a switch component, FliM, at the flagellar motor which induces a change from counterclockwise to clockwise flagellar rotation. Shows autophosphatase activity which is enhanced by CheZ.


Cofactor:		Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
Subunit:		Interacts (phosphorylated CheY) with CheZ (via C-terminus). {ECO:0000269\|PubMed:16674976, ECO:0000269\|PubMed:18083806, ECO:0000269\|PubMed:9837737}.
Subcellular location:		Cytoplasm.
Ptm:		Phosphorylated by CheA or acetylated by acetyl-CoA synthetase, depending on which acetate metabolism pathway is available (By similarity). Dephosphorylated (inactivated) by CheZ. {ECO:0000250, ECO:0000269\|PubMed:1902474, ECO:0000269\|PubMed:3280143}.