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UniProt functional annotation for P34024 | ||
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| UniProt code: P34024. |
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| Organism: | |
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria. |
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| Function: | |
Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Important factor in pathogenesis, PI-PLC activity is present only in virulent listeria species. It may participate in the lysis of the phagolysosomal membrane. |
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| Catalytic activity: | |
Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1D-myo- inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol; Xref=Rhea:RHEA:17093, ChEBI:CHEBI:17815, ChEBI:CHEBI:57880, ChEBI:CHEBI:58484; EC=4.6.1.13; |
| Subunit: | |
Monomer. |
| Subcellular location: | |
Secreted. Cytoplasm. Note=Secreted and, to a lesser extent, cytoplasmic. |
Annotations taken from UniProtKB at the EBI.