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PDBsum entry 2pbn
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References listed in PDB file
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Key reference
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Title
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Structural genomics of protein phosphatases.
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Authors
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S.C.Almo,
J.B.Bonanno,
J.M.Sauder,
S.Emtage,
T.P.Dilorenzo,
V.Malashkevich,
S.R.Wasserman,
S.Swaminathan,
S.Eswaramoorthy,
R.Agarwal,
D.Kumaran,
M.Madegowda,
S.Ragumani,
Y.Patskovsky,
J.Alvarado,
U.A.Ramagopal,
J.Faber-Barata,
M.R.Chance,
A.Sali,
A.Fiser,
Z.Y.Zhang,
D.S.Lawrence,
S.K.Burley.
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Ref.
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J Struct Funct Genomics, 2007,
8,
121-140.
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PubMed id
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Abstract
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The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS
Protein Structure Initiative (PSI) has applied its high-throughput X-ray
crystallographic structure determination platform to systematic studies of all
human protein phosphatases and protein phosphatases from biomedically-relevant
pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein
phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma
gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping
sickness, and 2 from the principal mosquito vector of malaria in Africa,
Anopheles gambiae. These structures provide insights into both normal and
pathophysiologic processes, including transcriptional regulation, regulation of
major signaling pathways, neural development, and type 1 diabetes. In
conjunction with the contributions of other international structural genomics
consortia, these efforts promise to provide an unprecedented database and
materials repository for structure-guided experimental and computational
discovery of inhibitors for all classes of protein phosphatases.
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