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* Residue conservation analysis
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PDB id:
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Signaling protein
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Title:
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Mechanism of auxin perception by the tir1 ubiquitin ligase
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Structure:
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Skp1-like protein 1a. Chain: a. Synonym: skp1-like 1, ufo-binding protein 1. Engineered: yes. Transport inhibitor response 1 protein. Chain: b. Synonym: f-box/lrr-repeat protein 1. Engineered: yes
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Source:
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Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Gene: skp1a, ask1, skp1, uip1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: tir1, fbl1, wei1.
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Resolution:
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2.21Å
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R-factor:
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0.163
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R-free:
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0.237
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Authors:
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X.Tan,L.I.A.Calderon-Villalobos,M.Sharon,C.V.Robinson,M.Estelle, N.Zheng
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Key ref:
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X.Tan
et al.
(2007).
Mechanism of auxin perception by the TIR1 ubiquitin ligase.
Nature,
446,
640-645.
PubMed id:
DOI:
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Date:
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06-Mar-07
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Release date:
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10-Apr-07
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PROCHECK
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Headers
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References
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DOI no:
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Nature
446:640-645
(2007)
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PubMed id:
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Mechanism of auxin perception by the TIR1 ubiquitin ligase.
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X.Tan,
L.I.Calderon-Villalobos,
M.Sharon,
C.Zheng,
C.V.Robinson,
M.Estelle,
N.Zheng.
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ABSTRACT
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Auxin is a pivotal plant hormone that controls many aspects of plant growth and
development. Perceived by a small family of F-box proteins including transport
inhibitor response 1 (TIR1), auxin regulates gene expression by promoting SCF
ubiquitin-ligase-catalysed degradation of the Aux/IAA transcription repressors,
but how the TIR1 F-box protein senses and becomes activated by auxin remains
unclear. Here we present the crystal structures of the Arabidopsis TIR1-ASK1
complex, free and in complexes with three different auxin compounds and an
Aux/IAA substrate peptide. These structures show that the leucine-rich repeat
domain of TIR1 contains an unexpected inositol hexakisphosphate co-factor and
recognizes auxin and the Aux/IAA polypeptide substrate through a single surface
pocket. Anchored to the base of the TIR1 pocket, auxin binds to a partially
promiscuous site, which can also accommodate various auxin analogues. Docked on
top of auxin, the Aux/IAA substrate peptide occupies the rest of the TIR1 pocket
and completely encloses the hormone-binding site. By filling in a hydrophobic
cavity at the protein interface, auxin enhances the TIR1-substrate interactions
by acting as a 'molecular glue'. Our results establish the first structural
model of a plant hormone receptor.
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Selected figure(s)
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Figure 1.
Figure 1: Crystal structure of the TIR1–ASK1 complex with
auxin and the IAA7 degron peptide. a, b, Two views of the
complex structure are shown as a ribbon diagram. TIR1, ASK1 and
the IAA7 substrate peptide are coloured grey, blue and orange,
respectively. The F-box and LRR domains of TIR1 are labelled.
Auxin is represented by a space-filling model (CPK). The InsP[6]
molecule is shown as a stick model.
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Figure 6.
Figure 6: A model of auxin-regulated TIR1–substrate
interactions. A schematic diagram of auxin functioning
as a 'molecular glue' to enhance TIR1–substrate interactions.
In contrast to an allosteric mechanism, auxin binds to the same
TIR1 pocket that docks the Aux/IAA substrate. Without inducing
significant conformational changes in its receptor, auxin
increases the affinity of two proteins by simultaneously
interacting with both in a cavity at the protein interface.
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The above figures are
reprinted
by permission from Macmillan Publishers Ltd:
Nature
(2007,
446,
640-645)
copyright 2007.
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Figures were
selected
by an automated process.
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Literature references that cite this PDB file's key reference
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PubMed id
|
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Reference
|
|
|
|
|
|
G.Brunoud,
D.M.Wells,
M.Oliva,
A.Larrieu,
V.Mirabet,
A.H.Burrow,
T.Beeckman,
S.Kepinski,
J.Traas,
M.J.Bennett,
and
T.Vernoux
(2012).
A novel sensor to map auxin response and distribution at high spatio-temporal resolution.
|
| |
Nature,
482,
103-106.
|
|
|
|
|
|
|
Z.Q.Fu,
S.Yan,
A.Saleh,
W.Wang,
J.Ruble,
N.Oka,
R.Mohan,
S.H.Spoel,
Y.Tada,
N.Zheng,
and
X.Dong
(2012).
NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants.
|
| |
Nature,
486,
228-232.
|
|
|
|
|
|
|
A.Mosblech,
C.Thurow,
C.Gatz,
I.Feussner,
and
I.Heilmann
(2011).
Jasmonic acid perception by COI1 involves inositol polyphosphates in Arabidopsis thaliana.
|
| |
Plant J,
65,
949-957.
|
|
|
|
|
|
|
A.Shen,
P.J.Lupardus,
M.M.Gersch,
A.W.Puri,
V.E.Albrow,
K.C.Garcia,
and
M.Bogyo
(2011).
Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins.
|
| |
Nat Struct Mol Biol,
18,
364-371.
|
|
|
PDB code:
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|
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|
|
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C.Nibau,
D.J.Gibbs,
K.A.Bunting,
L.A.Moody,
E.J.Smiles,
J.A.Tubby,
S.J.Bradshaw,
and
J.C.Coates
(2011).
ARABIDILLO proteins have a novel and conserved domain structure important for the regulation of their stability.
|
| |
Plant Mol Biol,
75,
77-92.
|
|
|
|
|
|
|
D.M.Duda,
D.C.Scott,
M.F.Calabrese,
E.S.Zimmerman,
N.Zheng,
and
B.A.Schulman
(2011).
Structural regulation of cullin-RING ubiquitin ligase complexes.
|
| |
Curr Opin Struct Biol,
21,
257-264.
|
|
|
|
|
|
|
F.Maier,
S.Zwicker,
A.Hückelhoven,
M.Meissner,
J.Funk,
A.J.Pfitzner,
and
U.M.Pfitzner
(2011).
NONEXPRESSOR OF PATHOGENESIS-RELATED PROTEINS1 (NPR1) and some NPR1-related proteins are sensitive to salicylic acid.
|
| |
Mol Plant Pathol,
12,
73-91.
|
|
|
|
|
|
|
L.A.Brown,
C.O'Leary-Steele,
P.Brookes,
L.Armitage,
S.Kepinski,
S.L.Warriner,
and
A.Baker
(2011).
A small molecule with differential effects on the PTS1 and PTS2 peroxisome matrix import pathways.
|
| |
Plant J,
65,
980-990.
|
|
|
|
|
|
|
M.Kanke,
K.Nishimura,
M.Kanemaki,
T.Kakimoto,
T.S.Takahashi,
T.Nakagawa,
and
H.Masukata
(2011).
Auxin-inducible protein depletion system in fission yeast.
|
| |
BMC Cell Biol,
12,
8.
|
|
|
|
|
|
|
O.Leyser
(2011).
Auxin, self-organisation, and the colonial nature of plants.
|
| |
Curr Biol,
21,
R331-R337.
|
|
|
|
|
|
|
R.Ortiz-Castro,
C.Díaz-Pérez,
M.Martínez-Trujillo,
R.E.del Río,
J.Campos-García,
and
J.López-Bucio
(2011).
Transkingdom signaling based on bacterial cyclodipeptides with auxin activity in plants.
|
| |
Proc Natl Acad Sci U S A,
108,
7253-7258.
|
|
|
|
|
|
|
S.Depuydt,
and
C.S.Hardtke
(2011).
Hormone signalling crosstalk in plant growth regulation.
|
| |
Curr Biol,
21,
R365-R373.
|
|
|
|
|
|
|
S.Meldau,
I.T.Baldwin,
and
J.Wu
(2011).
SGT1 regulates wounding- and herbivory-induced jasmonic acid accumulation and Nicotiana attenuata's resistance to the specialist lepidopteran herbivore Manduca sexta.
|
| |
New Phytol,
189,
1143-1156.
|
|
|
|
|
|
|
T.J.Chiou,
and
S.I.Lin
(2011).
Signaling network in sensing phosphate availability in plants.
|
| |
Annu Rev Plant Biol,
62,
185-206.
|
|
|
|
|
|
|
T.P.Sun
(2011).
The Molecular Mechanism and Evolution of the GA-GID1-DELLA Signaling Module in Plants.
|
| |
Curr Biol,
21,
R338-R345.
|
|
|
|
|
|
|
T.Vernoux,
G.Brunoud,
E.Farcot,
V.Morin,
H.Van den Daele,
J.Legrand,
M.Oliva,
P.Das,
A.Larrieu,
D.Wells,
Y.Guédon,
L.Armitage,
F.Picard,
S.Guyomarc'h,
C.Cellier,
G.Parry,
R.Koumproglou,
J.H.Doonan,
M.Estelle,
C.Godin,
S.Kepinski,
M.Bennett,
L.De Veylder,
and
J.Traas
(2011).
The auxin signalling network translates dynamic input into robust patterning at the shoot apex.
|
| |
Mol Syst Biol,
7,
508.
|
|
|
|
|
|
|
Y.Niu,
P.Figueroa,
and
J.Browse
(2011).
Characterization of JAZ-interacting bHLH transcription factors that regulate jasmonate responses in Arabidopsis.
|
| |
J Exp Bot,
62,
2143-2154.
|
|
|
|
|
|
|
Z.Hua,
and
R.D.Vierstra
(2011).
The cullin-RING ubiquitin-protein ligases.
|
| |
Annu Rev Plant Biol,
62,
299-334.
|
|
|
|
|
|
|
A.Santner,
and
M.Estelle
(2010).
The ubiquitin-proteasome system regulates plant hormone signaling.
|
| |
Plant J,
61,
1029-1040.
|
|
|
|
|
|
|
E.A.Vidal,
V.Araus,
C.Lu,
G.Parry,
P.J.Green,
G.M.Coruzzi,
and
R.A.Gutiérrez
(2010).
Nitrate-responsive miR393/AFB3 regulatory module controls root system architecture in Arabidopsis thaliana.
|
| |
Proc Natl Acad Sci U S A,
107,
4477-4482.
|
|
|
|
|
|
|
E.Heard,
S.Tishkoff,
J.A.Todd,
M.Vidal,
G.P.Wagner,
J.Wang,
D.Weigel,
and
R.Young
(2010).
Ten years of genetics and genomics: what have we achieved and where are we heading?
|
| |
Nat Rev Genet,
11,
723-733.
|
|
|
|
|
|
|
G.F.Hao,
and
G.F.Yang
(2010).
The role of Phe82 and Phe351 in auxin-induced substrate perception by TIR1 ubiquitin ligase: a novel insight from molecular dynamics simulations.
|
| |
PLoS One,
5,
e10742.
|
|
|
|
|
|
|
I.Szostkiewicz,
K.Richter,
M.Kepka,
S.Demmel,
Y.Ma,
A.Korte,
F.F.Assaad,
A.Christmann,
and
E.Grill
(2010).
Closely related receptor complexes differ in their ABA selectivity and sensitivity.
|
| |
Plant J,
61,
25-35.
|
|
|
|
|
|
|
J.H.Doonan,
and
R.Sablowski
(2010).
Walls around tumours - why plants do not develop cancer.
|
| |
Nat Rev Cancer,
10,
794-802.
|
|
|
|
|
|
|
J.H.Jung,
M.Lee,
and
C.M.Park
(2010).
A transcriptional feedback loop modulating signaling crosstalks between auxin and brassinosteroid in Arabidopsis.
|
| |
Mol Cells,
29,
449-456.
|
|
|
|
|
|
|
J.Liu,
and
R.Nussinov
(2010).
Molecular dynamics reveal the essential role of linker motions in the function of cullin-RING E3 ligases.
|
| |
J Mol Biol,
396,
1508-1523.
|
|
|
|
|
|
|
J.Muschietti,
and
S.McCormick
(2010).
Abscisic acid (ABA) receptors: light at the end of the tunnel.
|
| |
F1000 Biol Rep,
2,
0.
|
|
|
|
|
|
|
L.B.Sheard,
X.Tan,
H.Mao,
J.Withers,
G.Ben-Nissan,
T.R.Hinds,
Y.Kobayashi,
F.F.Hsu,
M.Sharon,
J.Browse,
S.Y.He,
J.Rizo,
G.A.Howe,
and
N.Zheng
(2010).
Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor.
|
| |
Nature,
468,
400-405.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
L.I.Calderon-Villalobos,
X.Tan,
N.Zheng,
and
M.Estelle
(2010).
Auxin perception--structural insights.
|
| |
Cold Spring Harb Perspect Biol,
2,
a005546.
|
|
|
|
|
|
|
M.J.Prigge,
M.Lavy,
N.W.Ashton,
and
M.Estelle
(2010).
Physcomitrella patens auxin-resistant mutants affect conserved elements of an auxin-signaling pathway.
|
| |
Curr Biol,
20,
1907-1912.
|
|
|
|
|
|
|
P.Overvoorde,
H.Fukaki,
and
T.Beeckman
(2010).
Auxin control of root development.
|
| |
Cold Spring Harb Perspect Biol,
2,
a001537.
|
|
|
|
|
|
|
P.Robles,
D.Fleury,
H.Candela,
G.Cnops,
M.M.Alonso-Peral,
S.Anami,
A.Falcone,
C.Caldana,
L.Willmitzer,
M.R.Ponce,
M.Van Lijsebettens,
and
J.L.Micol
(2010).
The RON1/FRY1/SAL1 gene is required for leaf morphogenesis and venation patterning in Arabidopsis.
|
| |
Plant Physiol,
152,
1357-1372.
|
|
|
|
|
|
|
P.W.Majerus,
D.B.Wilson,
C.Zhang,
P.J.Nicholas,
and
M.P.Wilson
(2010).
Expression of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) and its role in neural tube defects.
|
| |
Adv Enzyme Regul,
50,
365-372.
|
|
|
|
|
|
|
R.Carranco,
J.M.Espinosa,
P.Prieto-Dapena,
C.Almoguera,
and
J.Jordano
(2010).
Repression by an auxin/indole acetic acid protein connects auxin signaling with heat shock factor-mediated seed longevity.
|
| |
Proc Natl Acad Sci U S A,
107,
21908-21913.
|
|
|
|
|
|
|
R.E.Salinas-Mondragon,
J.D.Kajla,
I.Y.Perera,
C.S.Brown,
and
H.W.Sederoff
(2010).
Role of inositol 1,4,5-triphosphate signalling in gravitropic and phototropic gene expression.
|
| |
Plant Cell Environ,
33,
2041-2055.
|
|
|
|
|
|
|
R.Mittal,
S.Y.Peak-Chew,
R.S.Sade,
Y.Vallis,
and
H.T.McMahon
(2010).
The acetyltransferase activity of the bacterial toxin YopJ of Yersinia is activated by eukaryotic host cell inositol hexakisphosphate.
|
| |
J Biol Chem,
285,
19927-19934.
|
|
|
|
|
|
|
S.Lumba,
S.Cutler,
and
P.McCourt
(2010).
Plant nuclear hormone receptors: a role for small molecules in protein-protein interactions.
|
| |
Annu Rev Cell Dev Biol,
26,
445-469.
|
|
|
|
|
|
|
S.P.Pandey,
M.Roccaro,
M.Schön,
E.Logemann,
and
I.E.Somssich
(2010).
Transcriptional reprogramming regulated by WRKY18 and WRKY40 facilitates powdery mildew infection of Arabidopsis.
|
| |
Plant J,
64,
912-923.
|
|
|
|
|
|
|
T.Umezawa,
K.Nakashima,
T.Miyakawa,
T.Kuromori,
M.Tanokura,
K.Shinozaki,
and
K.Yamaguchi-Shinozaki
(2010).
Molecular basis of the core regulatory network in aba responses: sensing, signaling and transport.
|
| |
Plant Cell Physiol,
51,
1821-1839.
|
|
|
|
|
|
|
T.Vernoux,
F.Besnard,
and
J.Traas
(2010).
Auxin at the shoot apical meristem.
|
| |
Cold Spring Harb Perspect Biol,
2,
a001487.
|
|
|
|
|
|
|
T.W.Kim,
and
Z.Y.Wang
(2010).
Brassinosteroid signal transduction from receptor kinases to transcription factors.
|
| |
Annu Rev Plant Biol,
61,
681-704.
|
|
|
|
|
|
|
A.Chini,
M.Boter,
and
R.Solano
(2009).
Plant oxylipins: COI1/JAZs/MYC2 as the core jasmonic acid-signalling module.
|
| |
FEBS J,
276,
4682-4692.
|
|
|
|
|
|
|
A.S.Lokerse,
and
D.Weijers
(2009).
Auxin enters the matrix--assembly of response machineries for specific outputs.
|
| |
Curr Opin Plant Biol,
12,
520-526.
|
|
|
|
|
|
|
A.Santner,
and
M.Estelle
(2009).
Recent advances and emerging trends in plant hormone signalling.
|
| |
Nature,
459,
1071-1078.
|
|
|
|
|
|
|
A.Tromas,
N.Braun,
P.Muller,
T.Khodus,
I.A.Paponov,
K.Palme,
K.Ljung,
J.Y.Lee,
P.Benfey,
J.A.Murray,
B.Scheres,
and
C.Perrot-Rechenmann
(2009).
The AUXIN BINDING PROTEIN 1 is required for differential auxin responses mediating root growth.
|
| |
PLoS One,
4,
e6648.
|
|
|
|
|
|
|
B.Möller,
and
D.Weijers
(2009).
Auxin control of embryo patterning.
|
| |
Cold Spring Harbor Perspect Biol,
1,
a001545.
|
|
|
|
|
|
|
B.Molesini,
G.L.Rotino,
A.Spena,
and
T.Pandolfini
(2009).
Expression profile analysis of early fruit development in iaaM-parthenocarpic tomato plants.
|
| |
BMC Res Notes,
2,
143.
|
|
|
|
|
|
|
B.Singh,
H.D.Cheek,
and
C.H.Haigler
(2009).
A synthetic auxin (NAA) suppresses secondary wall cellulose synthesis and enhances elongation in cultured cotton fiber.
|
| |
Plant Cell Rep,
28,
1023-1032.
|
|
|
|
|
|
|
B.Veit
(2009).
Hormone mediated regulation of the shoot apical meristem.
|
| |
Plant Mol Biol,
69,
397-408.
|
|
|
|
|
|
|
C.L.Thomas,
D.Schmidt,
E.M.Bayer,
R.Dreos,
and
A.J.Maule
(2009).
Arabidopsis plant homeodomain finger proteins operate downstream of auxin accumulation in specifying the vasculature and primary root meristem.
|
| |
Plant J,
59,
426-436.
|
|
|
|
|
|
|
D.J.Lee,
J.W.Park,
H.W.Lee,
and
J.Kim
(2009).
Genome-wide analysis of the auxin-responsive transcriptome downstream of iaa1 and its expression analysis reveal the diversity and complexity of auxin-regulated gene expression.
|
| |
J Exp Bot,
60,
3935-3957.
|
|
|
|
|
|
|
D.R.Davies,
B.Mamat,
O.T.Magnusson,
J.Christensen,
M.H.Haraldsson,
R.Mishra,
B.Pease,
E.Hansen,
J.Singh,
D.Zembower,
H.Kim,
A.S.Kiselyov,
A.B.Burgin,
M.E.Gurney,
and
L.J.Stewart
(2009).
Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.
|
| |
J Med Chem,
52,
4694-4715.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
E.J.Chapman,
and
M.Estelle
(2009).
Mechanism of auxin-regulated gene expression in plants.
|
| |
Annu Rev Genet,
43,
265-285.
|
|
|
|
|
|
|
F.Carland,
and
T.Nelson
(2009).
CVP2- and CVL1-mediated phosphoinositide signaling as a regulator of the ARF GAP SFC/VAN3 in establishment of foliar vein patterns.
|
| |
Plant J,
59,
895-907.
|
|
|
|
|
|
|
F.d.o.s. .S.Maraschin,
J.Memelink,
and
R.Offringa
(2009).
Auxin-induced, SCF(TIR1)-mediated poly-ubiquitination marks AUX/IAA proteins for degradation.
|
| |
Plant J,
59,
100-109.
|
|
|
|
|
|
|
G.Parry,
L.I.Calderon-Villalobos,
M.Prigge,
B.Peret,
S.Dharmasiri,
H.Itoh,
E.Lechner,
W.M.Gray,
M.Bennett,
and
M.Estelle
(2009).
Complex regulation of the TIR1/AFB family of auxin receptors.
|
| |
Proc Natl Acad Sci U S A,
106,
22540-22545.
|
|
|
|
|
|
|
H.Yang,
and
A.S.Murphy
(2009).
Functional expression and characterization of Arabidopsis ABCB, AUX 1 and PIN auxin transporters in Schizosaccharomyces pombe.
|
| |
Plant J,
59,
179-191.
|
|
|
|
|
|
|
I.A.Paponov,
W.Teale,
D.Lang,
M.Paponov,
R.Reski,
S.A.Rensing,
and
K.Palme
(2009).
The evolution of nuclear auxin signalling.
|
| |
BMC Evol Biol,
9,
126.
|
|
|
|
|
|
|
J.Browse
(2009).
Jasmonate passes muster: a receptor and targets for the defense hormone.
|
| |
Annu Rev Plant Biol,
60,
183-205.
|
|
|
|
|
|
|
J.Gilkerson,
J.Hu,
J.Brown,
A.Jones,
T.P.Sun,
and
J.Callis
(2009).
Isolation and characterization of cul1-7, a recessive allele of CULLIN1 that disrupts SCF function at the C terminus of CUL1 in Arabidopsis thaliana.
|
| |
Genetics,
181,
945-963.
|
|
|
|
|
|
|
J.J.Holland,
D.Roberts,
and
E.Liscum
(2009).
Understanding phototropism: from Darwin to today.
|
| |
J Exp Bot,
60,
1969-1978.
|
|
|
|
|
|
|
J.Liu,
and
R.Nussinov
(2009).
The mechanism of ubiquitination in the cullin-RING E3 ligase machinery: conformational control of substrate orientation.
|
| |
PLoS Comput Biol,
5,
e1000527.
|
|
|
|
|
|
|
K.Kazan,
and
J.M.Manners
(2009).
Linking development to defense: auxin in plant-pathogen interactions.
|
| |
Trends Plant Sci,
14,
373-382.
|
|
|
|
|
|
|
K.L.Hindle,
J.Bella,
and
S.C.Lovell
(2009).
Quantitative analysis and prediction of curvature in leucine-rich repeat proteins.
|
| |
Proteins,
77,
342-358.
|
|
|
|
|
|
|
K.Nishimura,
T.Fukagawa,
H.Takisawa,
T.Kakimoto,
and
M.Kanemaki
(2009).
An auxin-based degron system for the rapid depletion of proteins in nonplant cells.
|
| |
Nat Methods,
6,
917-922.
|
|
|
|
|
|
|
L.B.Sheard,
and
N.Zheng
(2009).
Plant biology: Signal advance for abscisic acid.
|
| |
Nature,
462,
575-576.
|
|
|
|
|
|
|
L.Moubayidin,
R.Di Mambro,
and
S.Sabatini
(2009).
Cytokinin-auxin crosstalk.
|
| |
Trends Plant Sci,
14,
557-562.
|
|
|
|
|
|
|
M.Mishkind,
J.E.Vermeer,
E.Darwish,
and
T.Munnik
(2009).
Heat stress activates phospholipase D and triggers PIP accumulation at the plasma membrane and nucleus.
|
| |
Plant J,
60,
10-21.
|
|
|
|
|
|
|
N.Nishimura,
K.Hitomi,
A.S.Arvai,
R.P.Rambo,
C.Hitomi,
S.R.Cutler,
J.I.Schroeder,
and
E.D.Getzoff
(2009).
Structural Mechanism of Abscisic Acid Binding and Signaling by Dimeric PYR1.
|
| |
Science,
326,
1373-1379.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
R.D.Vierstra
(2009).
The ubiquitin-26S proteasome system at the nexus of plant biology.
|
| |
Nat Rev Mol Cell Biol,
10,
385-397.
|
|
|
|
|
|
|
R.J.Deshaies,
and
C.A.Joazeiro
(2009).
RING domain E3 ubiquitin ligases.
|
| |
Annu Rev Biochem,
78,
399-434.
|
|
|
|
|
|
|
S.E.Ploense,
M.F.Wu,
P.Nagpal,
and
J.W.Reed
(2009).
A gain-of-function mutation in IAA18 alters Arabidopsis embryonic apical patterning.
|
| |
Development,
136,
1509-1517.
|
|
|
|
|
|
|
S.Sonnberg,
S.B.Fleming,
and
A.A.Mercer
(2009).
A truncated two-{alpha}-helix F-box present in poxvirus ankyrin-repeat proteins is sufficient for binding the SCF1 ubiquitin ligase complex.
|
| |
J Gen Virol,
90,
1224-1228.
|
|
|
|
|
|
|
S.Tashiro,
C.E.Tian,
M.K.Watahiki,
and
K.T.Yamamoto
(2009).
Changes in growth kinetics of stamen filaments cause inefficient pollination in massugu2, an auxin insensitive, dominant mutant of Arabidopsis thaliana.
|
| |
Physiol Plant,
137,
175-187.
|
|
|
|
|
|
|
S.Vanneste,
and
J.Friml
(2009).
Auxin: a trigger for change in plant development.
|
| |
Cell,
136,
1005-1016.
|
|
|
|
|
|
|
T.Ceserani,
A.Trofka,
N.Gandotra,
and
T.Nelson
(2009).
VH1/BRL2 receptor-like kinase interacts with vascular-specific adaptor proteins VIT and VIK to influence leaf venation.
|
| |
Plant J,
57,
1000-1014.
|
|
|
|
|
|
|
T.Munnik,
and
C.Testerink
(2009).
Plant phospholipid signaling: "in a nutshell".
|
| |
J Lipid Res,
50,
S260-S265.
|
|
|
|
|
|
|
X.Tan,
and
N.Zheng
(2009).
Hormone signaling through protein destruction: a lesson from plants.
|
| |
Am J Physiol Endocrinol Metab,
296,
E223-E227.
|
|
|
|
|
|
|
A.K.Spartz,
and
W.M.Gray
(2008).
Plant hormone receptors: new perceptions.
|
| |
Genes Dev,
22,
2139-2148.
|
|
|
|
|
|
|
A.M.Murphy,
B.Otto,
C.A.Brearley,
J.P.Carr,
and
D.E.Hanke
(2008).
A role for inositol hexakisphosphate in the maintenance of basal resistance to plant pathogens.
|
| |
Plant J,
56,
638-652.
|
|
|
|
|
|
|
A.R.Alcázar-Román,
and
S.R.Wente
(2008).
Inositol polyphosphates: a new frontier for regulating gene expression.
|
| |
Chromosoma,
117,
1.
|
|
|
|
|
|
|
A.R.Stiles,
X.Qian,
S.B.Shears,
and
E.A.Grabau
(2008).
Metabolic and signaling properties of an Itpk gene family in Glycine max.
|
| |
FEBS Lett,
582,
1853-1858.
|
|
|
|
|
|
|
A.Sato,
and
K.T.Yamamoto
(2008).
Overexpression of the non-canonical Aux/IAA genes causes auxin-related aberrant phenotypes in Arabidopsis.
|
| |
Physiol Plant,
133,
397-405.
|
|
|
|
|
|
|
A.Sato,
and
K.T.Yamamoto
(2008).
What's the physiological role of domain II-less Aux/IAA proteins?
|
| |
Plant Signal Behav,
3,
496-497.
|
|
|
|
|
|
|
A.Ueda,
P.Li,
Y.Feng,
M.Vikram,
S.Kim,
C.H.Kang,
J.S.Kang,
J.D.Bahk,
S.Y.Lee,
T.Fukuhara,
P.E.Staswick,
A.E.Pepper,
and
H.Koiwa
(2008).
The Arabidopsis thaliana carboxyl-terminal domain phosphatase-like 2 regulates plant growth, stress and auxin responses.
|
| |
Plant Mol Biol,
67,
683-697.
|
|
|
|
|
|
|
A.V.Kajava,
M.Anisimova,
and
N.Peeters
(2008).
Origin and evolution of GALA-LRR, a new member of the CC-LRR subfamily: from plants to bacteria?
|
| |
PLoS ONE,
3,
e1694.
|
|
|
|
|
|
|
C.Delker,
A.Raschke,
and
M.Quint
(2008).
Auxin dynamics: the dazzling complexity of a small molecule's message.
|
| |
Planta,
227,
929-941.
|
|
|
|
|
|
|
G.A.Howe,
and
G.Jander
(2008).
Plant immunity to insect herbivores.
|
| |
Annu Rev Plant Biol,
59,
41-66.
|
|
|
|
|
|
|
H.Park,
J.Huxley-Jones,
R.P.Boot-Handford,
P.N.Bishop,
T.K.Attwood,
and
J.Bella
(2008).
LRRCE: a leucine-rich repeat cysteine capping motif unique to the chordate lineage.
|
| |
BMC Genomics,
9,
599.
|
|
|
|
|
|
|
I.Heilmann
(2008).
Towards understanding the function of stress-inducible PtdIns(4,5)P(2) in plants.
|
| |
Commun Integr Biol,
1,
204-206.
|
|
|
|
|
|
|
J.C.Cheung,
B.Salerno,
and
L.A.Hanakahi
(2008).
Evidence for an inositol hexakisphosphate-dependent role for Ku in mammalian nonhomologous end joining that is independent of its role in the DNA-dependent protein kinase.
|
| |
Nucleic Acids Res,
36,
5713-5726.
|
|
|
|
|
|
|
J.D.York,
and
D.J.Lew
(2008).
IP7 guards the CDK gate.
|
| |
Nat Chem Biol,
4,
16-17.
|
|
|
|
|
|
|
J.M.Chico,
A.Chini,
S.Fonseca,
and
R.Solano
(2008).
JAZ repressors set the rhythm in jasmonate signaling.
|
| |
Curr Opin Plant Biol,
11,
486-494.
|
|
|
|
|
|
|
J.Salmon,
J.Ramos,
and
J.Callis
(2008).
Degradation of the auxin response factor ARF1.
|
| |
Plant J,
54,
118-128.
|
|
|
|
|
|
|
J.Stuttmann,
J.E.Parker,
and
L.D.Noël
(2008).
Staying in the fold: The SGT1/chaperone machinery in maintenance and evolution of leucine-rich repeat proteins.
|
| |
Plant Signal Behav,
3,
283-285.
|
|
|
|
|
|
|
J.Vadassery,
C.Ritter,
Y.Venus,
I.Camehl,
A.Varma,
B.Shahollari,
O.Novák,
M.Strnad,
J.Ludwig-Müller,
and
R.Oelmüller
(2008).
The role of auxins and cytokinins in the mutualistic interaction between Arabidopsis and Piriformospora indica.
|
| |
Mol Plant Microbe Interact,
21,
1371-1383.
|
|
|
|
|
|
|
J.W.Chandler
(2008).
Cotyledon organogenesis.
|
| |
J Exp Bot,
59,
2917-2931.
|
|
|
|
|
|
|
K.Hayashi,
X.Tan,
N.Zheng,
T.Hatate,
Y.Kimura,
S.Kepinski,
and
H.Nozaki
(2008).
Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling.
|
| |
Proc Natl Acad Sci U S A,
105,
5632-5637.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
K.Hirano,
M.Ueguchi-Tanaka,
and
M.Matsuoka
(2008).
GID1-mediated gibberellin signaling in plants.
|
| |
Trends Plant Sci,
13,
192-199.
|
|
|
|
|
|
|
K.Matsui,
Y.Umemura,
and
M.Ohme-Takagi
(2008).
AtMYBL2, a protein with a single MYB domain, acts as a negative regulator of anthocyanin biosynthesis in Arabidopsis.
|
| |
Plant J,
55,
954-967.
|
|
|
|
|
|
|
K.Mockaitis,
and
M.Estelle
(2008).
Auxin receptors and plant development: a new signaling paradigm.
|
| |
Annu Rev Cell Dev Biol,
24,
55-80.
|
|
|
|
|
|
|
K.Murase,
Y.Hirano,
T.P.Sun,
and
T.Hakoshima
(2008).
Gibberellin-induced DELLA recognition by the gibberellin receptor GID1.
|
| |
Nature,
456,
459-463.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
K.Prochazkova,
and
K.J.Satchell
(2008).
Structure-Function Analysis of Inositol Hexakisphosphate-induced Autoprocessing of the Vibrio cholerae Multifunctional Autoprocessing RTX Toxin.
|
| |
J Biol Chem,
283,
23656-23664.
|
|
|
|
|
|
|
L.C.Li,
G.J.Qin,
T.Tsuge,
X.H.Hou,
M.Y.Ding,
T.Aoyama,
A.Oka,
Z.Chen,
H.Gu,
Y.Zhao,
and
L.J.Qu
(2008).
SPOROCYTELESS modulates YUCCA expression to regulate the development of lateral organs in Arabidopsis.
|
| |
New Phytol,
179,
751-764.
|
|
|
|
|
|
|
L.C.Strader,
M.Monroe-Augustus,
and
B.Bartel
(2008).
The IBR5 phosphatase promotes Arabidopsis auxin responses through a novel mechanism distinct from TIR1-mediated repressor degradation.
|
| |
BMC Plant Biol,
8,
41.
|
|
|
|
|
|
|
L.Katsir,
A.L.Schilmiller,
P.E.Staswick,
S.Y.He,
and
G.A.Howe
(2008).
COI1 is a critical component of a receptor for jasmonate and the bacterial virulence factor coronatine.
|
| |
Proc Natl Acad Sci U S A,
105,
7100-7105.
|
|
|
|
|
|
|
L.Katsir,
H.S.Chung,
A.J.Koo,
and
G.A.Howe
(2008).
Jasmonate signaling: a conserved mechanism of hormone sensing.
|
| |
Curr Opin Plant Biol,
11,
428-435.
|
|
|
|
|
|
|
M.Christian,
W.B.Hannah,
H.Lüthen,
and
A.M.Jones
(2008).
Identification of auxins by a chemical genomics approach.
|
| |
J Exp Bot,
59,
2757-2767.
|
|
|
|
|
|
|
M.Melotto,
C.Mecey,
Y.Niu,
H.S.Chung,
L.Katsir,
J.Yao,
W.Zeng,
B.Thines,
P.Staswick,
J.Browse,
G.A.Howe,
and
S.Y.He
(2008).
A critical role of two positively charged amino acids in the Jas motif of Arabidopsis JAZ proteins in mediating coronatine- and jasmonoyl isoleucine-dependent interactions with the COI1 F-box protein.
|
| |
Plant J,
55,
979-988.
|
|
|
|
|
|
|
M.Melotto,
W.Underwood,
and
S.Y.He
(2008).
Role of stomata in plant innate immunity and foliar bacterial diseases.
|
| |
Annu Rev Phytopathol,
46,
101-122.
|
|
|
|
|
|
|
N.Mitsuhashi,
M.Kondo,
S.Nakaune,
M.Ohnishi,
M.Hayashi,
I.Hara-Nishimura,
A.Richardson,
H.Fukaki,
M.Nishimura,
and
T.Mimura
(2008).
Localization of myo-inositol-1-phosphate synthase to the endosperm in developing seeds of Arabidopsis.
|
| |
J Exp Bot,
59,
3069-3076.
|
|
|
|
|
|
|
P.E.Staswick
(2008).
JAZing up jasmonate signaling.
|
| |
Trends Plant Sci,
13,
66-71.
|
|
|
|
|
|
|
P.Hedden
(2008).
Plant biology: Gibberellins close the lid.
|
| |
Nature,
456,
455-456.
|
|
|
|
|
|
|
R.Benjamins,
and
B.Scheres
(2008).
Auxin: the looping star in plant development.
|
| |
Annu Rev Plant Biol,
59,
443-465.
|
|
|
|
|
|
|
R.H.Michell
(2008).
Inositol derivatives: evolution and functions.
|
| |
Nat Rev Mol Cell Biol,
9,
151-161.
|
|
|
|
|
|
|
S.Jurado,
S.Díaz-Triviño,
Z.Abraham,
C.Manzano,
C.Gutierrez,
and
C.del Pozo
(2008).
SKP2A, an F-box protein that regulates cell division, is degraded via the ubiquitin pathway.
|
| |
Plant J,
53,
828-841.
|
|
|
|
|
|
|
S.Jurado,
S.D.Triviño,
Z.Abraham,
C.Manzano,
C.Gutierrez,
and
C.Del Pozo
(2008).
SKP2A protein, an F-box that regulates cell division, is degraded via the ubiquitin pathway.
|
| |
Plant Signal Behav,
3,
810-812.
|
|
|
|
|
|
|
T.Ravid,
and
M.Hochstrasser
(2008).
Diversity of degradation signals in the ubiquitin-proteasome system.
|
| |
Nat Rev Mol Cell Biol,
9,
679-690.
|
|
|
|
|
|
|
T.Uehara,
Y.Okushima,
T.Mimura,
M.Tasaka,
and
H.Fukaki
(2008).
Domain II mutations in CRANE/IAA18 suppress lateral root formation and affect shoot development in Arabidopsis thaliana.
|
| |
Plant Cell Physiol,
49,
1025-1038.
|
|
|
|
|
|
|
X.H.Gao,
X.Z.Huang,
S.L.Xiao,
and
X.D.Fu
(2008).
Evolutionarily conserved DELLA-mediated gibberellin signaling in plants.
|
| |
J Integr Plant Biol,
50,
825-834.
|
|
|
|
|
|
|
A.Chini,
S.Fonseca,
G.Fernández,
B.Adie,
J.M.Chico,
O.Lorenzo,
G.García-Casado,
I.López-Vidriero,
F.M.Lozano,
M.R.Ponce,
J.L.Micol,
and
R.Solano
(2007).
The JAZ family of repressors is the missing link in jasmonate signalling.
|
| |
Nature,
448,
666-671.
|
|
|
|
|
|
|
A.D.Capili,
and
C.D.Lima
(2007).
Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways.
|
| |
Curr Opin Struct Biol,
17,
726-735.
|
|
|
|
|
|
|
B.Thines,
L.Katsir,
M.Melotto,
Y.Niu,
A.Mandaokar,
G.Liu,
K.Nomura,
S.Y.He,
G.A.Howe,
and
J.Browse
(2007).
JAZ repressor proteins are targets of the SCF(COI1) complex during jasmonate signalling.
|
| |
Nature,
448,
661-665.
|
|
|
|
|
|
|
C.S.Hardtke
(2007).
Transcriptional auxin-brassinosteroid crosstalk: who's talking?
|
| |
Bioessays,
29,
1115-1123.
|
|
|
|
|
|
|
C.S.Hardtke,
E.Dorcey,
K.S.Osmont,
and
R.Sibout
(2007).
Phytohormone collaboration: zooming in on auxin-brassinosteroid interactions.
|
| |
Trends Cell Biol,
17,
485-492.
|
|
|
|
|
|
|
C.Sungur,
S.Miller,
J.Bergholz,
R.C.Hoye,
R.G.Brisbois,
and
P.Overvoorde
(2007).
The small molecule 2-furylacrylic acid inhibits auxin-mediated responses in Arabidopsis thaliana.
|
| |
Plant Cell Physiol,
48,
1693-1701.
|
|
|
|
|
|
|
H.Muto,
M.K.Watahiki,
and
K.T.Yamamoto
(2007).
What Makes each Aux/IAA Gene Unique in its Gene Family, Expression Pattern or Properties of the Gene Product?
|
| |
Plant Signal Behav,
2,
390-392.
|
|
|
|
|
|
|
J.C.Otto,
P.Kelly,
S.T.Chiou,
and
J.D.York
(2007).
Alterations in an inositol phosphate code through synergistic activation of a G protein and inositol phosphate kinases.
|
| |
Proc Natl Acad Sci U S A,
104,
15653-15658.
|
|
|
|
|
|
|
K.Grossmann
(2007).
Auxin herbicide action: lifting the veil step by step.
|
| |
Plant Signal Behav,
2,
421-423.
|
|
|
|
|
|
|
M.F.Covington,
and
S.L.Harmer
(2007).
The circadian clock regulates auxin signaling and responses in Arabidopsis.
|
| |
PLoS Biol,
5,
e222.
|
|
|
|
|
|
|
P.Knipscheer,
and
T.K.Sixma
(2007).
Protein-protein interactions regulate Ubl conjugation.
|
| |
Curr Opin Struct Biol,
17,
665-673.
|
|
|
|
|
|
|
S.Kepinski
(2007).
The anatomy of auxin perception.
|
| |
Bioessays,
29,
953-956.
|
|
|
|
|
|
|
S.L.Stone,
and
J.Callis
(2007).
Ubiquitin ligases mediate growth and development by promoting protein death.
|
| |
Curr Opin Plant Biol,
10,
624-632.
|
|
|
|
|
|
|
T.Guilfoyle
(2007).
Plant biology: sticking with auxin.
|
| |
Nature,
446,
621-622.
|
|
|
|
|
|
|
Y.Cheng,
G.Qin,
X.Dai,
and
Y.Zhao
(2007).
NPY1, a BTB-NPH3-like protein, plays a critical role in auxin-regulated organogenesis in Arabidopsis.
|
| |
Proc Natl Acad Sci U S A,
104,
18825-18829.
|
|
|
|
|
|
The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
|
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Links
