PDBsum entry 2ozf

Protein binding

PDB id: 2ozf

Contents

Protein chain

92 a.a. *

Waters ×150

* Residue conservation analysis

PDB id:

2ozf

Name:

Protein binding

Title:

The crystal structure of the 2nd pdz domain of the human nherf-1 (slc9a3r1)

Structure:

Ezrin-radixin-moesin-binding phosphoprotein 50. Chain: a. Fragment: second pdz domain. Synonym: ebp50, na+/h+ exchange regulatory cofactor nhe-rf, nherf-1, regulatory cofactor of na+/h+ exchanger, sodium-hydrogen exchanger regulatory factor 1, solute carrier family 9 isoform 3 regulatory factor 1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: slc9a3r1, nherf. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.50Å R-factor: 0.172 R-free: 0.211

Authors:

C.Phillips,E.Papagrigoriou,C.Gileadi,O.Fedorov,J.Elkins,G.Berridge, A.P.Turnbull,O.Gileadi,G.Schoch,C.Smee,J.Bray,P.Savitsky, J.Uppenberg,F.Von Delft,F.Gorrec,C.Umeano,E.Salah,S.Colebrook, J.Weigelt,C.H.Arrowsmith,A.Edwards,M.Sundstrom,D.A.Doyle,Structural Genomics Consortium (Sgc)

Key ref:

C.Phillips et al. The crystal structure of the 2nd pdz domain of the human nherf-1 (slc9a3r1). To be published, .

Date:

26-Feb-07 Release date: 13-Mar-07

Protein chain

O14745  (NHRF1_HUMAN) -  Na(+)/H(+) exchange regulatory cofactor NHE-RF1 from Homo sapiens

Seq: 358 a.a.

Struc: 92 a.a.*

* PDB and UniProt seqs differ at 6 residue positions (black crosses)