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UniProt functional annotation for P52272 | ||
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| UniProt code: P52272. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
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| Subunit: | |
Identified in the spliceosome C complex (PubMed:11991638). Interacts with PPIA/CYPA (PubMed:25678563). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:25678563}. |
| Subcellular location: | |
Nucleus, nucleolus {ECO:0000269|Ref.5}. |
| Ptm: | |
Sumoylated. {ECO:0000269|PubMed:15561718}. |
Annotations taken from UniProtKB at the EBI.