UniProt functional annotation for P04183

UniProt code: P04183.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Catalytic activity: ATP + thymidine = ADP + thymidine 5'- phosphate.
Subunit: Homotetramer. {ECO:0000269|PubMed:15611477, ECO:0000269|PubMed:15733844, ECO:0000269|PubMed:17407781}.
Subcellular location: Cytoplasm.
Ptm: Phosphorylated on Ser-13 in mitosis. {ECO:0000269|PubMed:9575153}.
Miscellaneous: Two forms have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.
Similarity: Belongs to the thymidine kinase family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.