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UniProt functional annotation for Q8R183 | ||
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| UniProt code: Q8R183. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Probable receptor for SEMA4A involved in the regulation of T- cell function. The interaction with SEMA4A enhances T-cell activation. {ECO:0000269|PubMed:12374982}. |
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| Subunit: | |
Homodimer. {ECO:0000269|PubMed:17363299}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:17363299}; Single-pass type I membrane protein {ECO:0000269|PubMed:17363299}. |
| Miscellaneous: | |
Belongs to the T-cell and airway phenotype regulator (Tapr) locus, a single chromosomal region that confers reduced T-helper type 2 responsiveness and protects against airway hyperactivity (AHR), the hallmark of human asthma. The human genomic locus appears to lack the Timd2 gene. |
| Similarity: | |
Belongs to the immunoglobulin superfamily. TIM family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.