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PDBsum entry 2oq1
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protein metals Protein-protein interface(s) links
Transferase PDB id
2oq1

 

 

 

 

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Contents
Protein chains
254 a.a. *
19 a.a. *
Metals
_PB
Waters ×342
* Residue conservation analysis
PDB id:
2oq1
Name: Transferase
Title: Tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
Structure: Tyrosine-protein kinase zap-70. Chain: a. Fragment: residues 3-256. Synonym: 70 kda zeta-associated protein, syk-related tyrosine kinase. Engineered: yes. T-cell surface glycoprotein cd3 zeta chain. Chain: b. Fragment: residues 69-87. Synonym: t-cell receptor t3 zeta chain, cd247 antigen.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence occurs naturally in homo sapiens (humans)
Resolution:
1.90Å     R-factor:   0.209     R-free:   0.255
Authors: M.H.Hatada,E.R.Laird,J.Green,J.Morgenstern,M.K.Ram
Key ref: M.H.Hatada et al. (1995). Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor. Nature, 377, 32-38. PubMed id: 7659156
Date:
30-Jan-07     Release date:   06-Mar-07    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P43403  (ZAP70_HUMAN) -  Tyrosine-protein kinase ZAP-70 from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		619 a.a.
254 a.a.
Protein chain
Pfam   ArchSchema ?
P20963  (CD3Z_HUMAN) -  T-cell surface glycoprotein CD3 zeta chain from Homo sapiens
Seq:
Struc: 		164 a.a.
19 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chain A: E.C.2.7.10.2  - non-specific protein-tyrosine kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
L-tyrosyl-[protein]
 + ATP
 = O-phospho-L-tyrosyl-[protein]
 + ADP
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    Added reference    
 
 
Nature 377:32-38 (1995)
PubMed id: 7659156  
 
 
Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor.
M.H.Hatada, X.Lu, E.R.Laird, J.Green, J.P.Morgenstern, M.Lou, C.S.Marr, T.B.Phillips, M.K.Ram, K.Theriault.
 
  ABSTRACT  
 
The crystal structure of the tandem SH2 domains of human ZAP-70 in complex with a peptide derived from the zeta-subunit of the T-cell receptor reveals an unanticipated interaction between the two domains. A coiled coil of alpha-helices connects the two SH2 domains, producing an interface that constitutes one of the two critical phosphotyrosine binding sites. These and other unique features provide the molecular basis for highly selective association of ZAP-70 with the T-cell receptor.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
20135127 A.Fischer, C.Picard, K.Chemin, S.Dogniaux, F.le Deist, and C.Hivroz (2010).
ZAP70: a master regulator of adaptive immunity.
  Semin Immunopathol, 32, 107-116.  
20193029 A.M.Kerrigan, and G.D.Brown (2010).
Syk-coupled C-type lectin receptors that mediate cellular activation via single tyrosine based activation motifs.
  Immunol Rev, 234, 335-352.  
  20001666 D.Ghosh, and G.C.Tsokos (2010).
Spleen tyrosine kinase: an Src family of non-receptor kinase has multiple functions and represents a valuable therapeutic target in the treatment of autoimmune and inflammatory diseases.
  Autoimmunity, 43, 48-55.  
  20452964 H.Wang, T.A.Kadlecek, B.B.Au-Yeung, H.E.Goodfellow, L.Y.Hsu, T.S.Freedman, and A.Weiss (2010).
ZAP-70: an essential kinase in T-cell signaling.
  Cold Spring Harb Perspect Biol, 2, a002279.  
  20452950 K.W.Wucherpfennig, E.Gagnon, M.J.Call, E.S.Huseby, and M.E.Call (2010).
Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.
  Cold Spring Harb Perspect Biol, 2, a005140.  
  20945976 M.Mallaun, G.Zenke, and E.Palmer (2010).
A discrete affinity-driven elevation of ZAP-70 kinase activity initiates negative selection.
  J Recept Signal Transduct Res, 30, 430-443.  
19290920 B.B.Au-Yeung, S.Deindl, L.Y.Hsu, E.H.Palacios, S.E.Levin, J.Kuriyan, and A.Weiss (2009).
The structure, regulation, and function of ZAP-70.
  Immunol Rev, 228, 41-57.  
19909352 C.S.Guy, and D.A.Vignali (2009).
Organization of proximal signal initiation at the TCR:CD3 complex.
  Immunol Rev, 232, 7.  
19298946 D.L.Farber (2009).
Biochemical signaling pathways for memory T cell recall.
  Semin Immunol, 21, 84-91.  
19714714 J.Kuil, L.T.van Wandelen, N.J.de Mol, and R.M.Liskamp (2009).
Switching between low and high affinity for the Syk tandem SH2 domain by irradiation of azobenzene containing ITAM peptidomimetics.
  J Pept Sci, 15, 685-691.  
19841086 L.Y.Hsu, Y.X.Tan, Z.Xiao, M.Malissen, and A.Weiss (2009).
A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity.
  J Exp Med, 206, 2527-2541.  
19920178 S.Deindl, T.A.Kadlecek, X.Cao, J.Kuriyan, and A.Weiss (2009).
Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response.
  Proc Natl Acad Sci U S A, 106, 20699-20704.  
19013279 C.Xu, E.Gagnon, M.E.Call, J.R.Schnell, C.D.Schwieters, C.V.Carman, J.J.Chou, and K.W.Wucherpfennig (2008).
Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif.
  Cell, 135, 702-713.
PDB code: 2k4f
18614237 J.A.Young, A.M.Becker, J.J.Medeiros, V.S.Shapiro, A.Wang, J.D.Farrar, T.A.Quill, R.Hooft van Huijsduijnen, and N.S.van Oers (2008).
The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions.
  Mol Immunol, 45, 3756-3766.  
18555270 K.Takeuchi, H.Yang, E.Ng, S.Y.Park, Z.Y.Sun, E.L.Reinherz, and G.Wagner (2008).
Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity.
  J Mol Biol, 380, 704-716.
PDB code: 2jxb
18728635 O.Acuto, V.D.Bartolo, and F.Michel (2008).
Tailoring T-cell receptor signals by proximal negative feedback mechanisms.
  Nat Rev Immunol, 8, 699-712.  
18689684 Y.Zhang, H.Oh, R.A.Burton, J.W.Burgner, R.L.Geahlen, and C.B.Post (2008).
Tyr130 phosphorylation triggers Syk release from antigen receptor by long-distance conformational uncoupling.
  Proc Natl Acad Sci U S A, 105, 11760-11765.  
18034420 D.Pargmann, R.Yücel, C.Kosan, I.Saba, L.Klein-Hitpass, S.Schimmer, F.Heyd, U.Dittmer, and T.Möröy (2007).
Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphocyte function.
  Eur J Immunol, 37, 3551-3563.  
17410622 E.Duchardt, A.B.Sigalov, D.Aivazian, L.J.Stern, and H.Schwalbe (2007).
Structure induction of the T-cell receptor zeta-chain upon lipid binding investigated by NMR spectroscopy.
  Chembiochem, 8, 820-827.  
17339324 G.L.Fuller, J.A.Williams, M.G.Tomlinson, J.A.Eble, S.L.Hanna, S.Pöhlmann, K.Suzuki-Inoue, Y.Ozaki, S.P.Watson, and A.C.Pearce (2007).
The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade.
  J Biol Chem, 282, 12397-12409.  
17164523 J.E.Ladbury (2007).
Measurement of the formation of complexes in tyrosine kinase-mediated signal transduction.
  Acta Crystallogr D Biol Crystallogr, 63, 26-31.  
17656366 M.D.Jennings, R.T.Blankley, M.Baron, A.P.Golovanov, and J.M.Avis (2007).
Specificity and autoregulation of Notch binding by tandem WW domains in suppressor of Deltex.
  J Biol Chem, 282, 29032-29042.
PDB code: 2jmf
17512407 S.Deindl, T.A.Kadlecek, T.Brdicka, X.Cao, A.Weiss, and J.Kuriyan (2007).
Structural basis for the inhibition of tyrosine kinase activity of ZAP-70.
  Cell, 129, 735-746.
PDB code: 2ozo
17624955 S.M.Grande, G.Bannish, E.M.Fuentes-Panana, E.Katz, and J.G.Monroe (2007).
Tonic B-cell and viral ITAM signaling: context is everything.
  Immunol Rev, 218, 214-234.  
17574014 T.A.Leonard, and J.H.Hurley (2007).
Two kinase family dramas.
  Cell, 129, 1037-1038.  
17317137 T.Pawson (2007).
Dynamic control of signaling by modular adaptor proteins.
  Curr Opin Cell Biol, 19, 112-116.  
16919488 A.Kumar, T.D.Humphreys, K.N.Kremer, P.S.Bramati, L.Bradfield, C.E.Edgar, and K.E.Hedin (2006).
CXCR4 physically associates with the T cell receptor to signal in T cells.
  Immunity, 25, 213-224.  
16829979 B.T.Seet, I.Dikic, M.M.Zhou, and T.Pawson (2006).
Reading protein modifications with interaction domains.
  Nat Rev Mol Cell Biol, 7, 473-483.  
16273093 R.B.Jones, A.Gordus, J.A.Krall, and G.MacBeath (2006).
A quantitative protein interaction network for the ErbB receptors using protein microarrays.
  Nature, 439, 168-174.  
16713715 S.Sakaguchi, N.Sakaguchi, H.Yoshitomi, H.Hata, T.Takahashi, and T.Nomura (2006).
Spontaneous development of autoimmune arthritis due to genetic anomaly of T cell signal transduction: Part 1.
  Semin Immunol, 18, 199-206.  
16908148 W.J.Choi, Z.D.Shi, K.M.Worthy, L.Bindu, R.G.Karki, M.C.Nicklaus, R.J.Fisher, and T.R.Burke (2006).
Application of azide-alkyne cycloaddition 'click chemistry' for the synthesis of Grb2 SH2 domain-binding macrocycles.
  Bioorg Med Chem Lett, 16, 5265-5269.  
15842733 A.Elkak, W.Al Sarakbi, and K.Mokbel (2005).
SYK expression in human breast cancer.
  J Carcinog, 4, 7.  
15914019 M.I.Catalina, M.J.Fischer, F.J.Dekker, R.M.Liskamp, and A.J.Heck (2005).
Binding of a diphosphorylated-ITAM peptide to spleen tyrosine kinase (Syk) induces distal conformational changes: a hydrogen exchange mass spectrometry study.
  J Am Soc Mass Spectrom, 16, 1039-1051.  
16185147 M.Ulanova, F.Duta, L.Puttagunta, A.D.Schreiber, and A.D.Befus (2005).
Spleen tyrosine kinase (Syk) as a novel target for allergic asthma and rhinitis.
  Expert Opin Ther Targets, 9, 901-921.  
16252296 N.J.de Mol, M.I.Catalina, F.J.Dekker, M.J.Fischer, A.J.Heck, and R.M.Liskamp (2005).
Protein flexibility and ligand rigidity: a thermodynamic and kinetic study of ITAM-based ligand binding to Syk tandem SH2.
  Chembiochem, 6, 2261-2270.  
15742383 U.Egner, J.Krätzschmar, B.Kreft, H.D.Pohlenz, and M.Schneider (2005).
The target discovery process.
  Chembiochem, 6, 468-479.  
15341721 G.Charier, J.Couprie, B.Alpha-Bazin, V.Meyer, E.Quéméneur, R.Guérois, I.Callebaut, B.Gilquin, and S.Zinn-Justin (2004).
The Tudor tandem of 53BP1: a new structural motif involved in DNA and RG-rich peptide binding.
  Structure, 12, 1551-1562.
PDB code: 1ssf
15292186 L.Jin, S.Pluskey, E.C.Petrella, S.M.Cantin, J.C.Gorga, M.J.Rynkiewicz, P.Pandey, J.E.Strickler, R.E.Babine, D.T.Weaver, and K.J.Seidl (2004).
The three-dimensional structure of the ZAP-70 kinase domain in complex with staurosporine: implications for the design of selective inhibitors.
  J Biol Chem, 279, 42818-42825.
PDB code: 1u59
14672952 M.S.Sozio, M.A.Mathis, J.A.Young, S.Wälchli, L.A.Pitcher, P.C.Wrage, B.Bartók, A.Campbell, J.D.Watts, R.Aebersold, R.H.Van Huijsduijnen, and N.S.van Oers (2004).
PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit.
  J Biol Chem, 279, 7760-7769.  
14648615 N.Gresh, and G.B.Shi (2004).
Conformation-dependent intermolecular interaction energies of the triphosphate anion with divalent metal cations. Application to the ATP-binding site of a binuclear bacterial enzyme. A parallel quantum chemical and polarizable molecular mechanics investigation.
  J Comput Chem, 25, 160-168.  
12614351 L.A.Pitcher, J.A.Young, M.A.Mathis, P.C.Wrage, B.Bartók, and N.S.van Oers (2003).
The formation and functions of the 21- and 23-kDa tyrosine-phosphorylated TCR zeta subunits.
  Immunol Rev, 191, 47-61.  
14552840 L.A.Pitcher, and N.S.van Oers (2003).
T-cell receptor signal transmission: who gives an ITAM?
  Trends Immunol, 24, 554-560.  
14555997 W.Feng, Y.Shi, M.Li, and M.Zhang (2003).
Tandem PDZ repeats in glutamate receptor-interacting proteins have a novel mode of PDZ domain-mediated target binding.
  Nat Struct Biol, 10, 972-978.
PDB codes: 1p1d 1p1e
12171941 D.G.Woodside, A.Obergfell, A.Talapatra, D.A.Calderwood, S.J.Shattil, and M.H.Ginsberg (2002).
The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains.
  J Biol Chem, 277, 39401-39408.  
12417718 J.Zhang, E.Berenstein, and R.P.Siraganian (2002).
Phosphorylation of Tyr342 in the linker region of Syk is critical for Fc epsilon RI signaling in mast cells.
  Mol Cell Biol, 22, 8144-8154.  
11861607 L.E.Samelson (2002).
Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins.
  Annu Rev Immunol, 20, 371-394.  
11514606 Q.Gong, X.Jin, A.M.Akk, N.Foger, M.White, G.Gong, J.Bubeck Wardenburg, and A.C.Chan (2001).
Requirement for tyrosine residues 315 and 319 within zeta chain-associated protein 70 for T cell development.
  J Exp Med, 194, 507-518.  
10704231 C.Visco, G.Magistrelli, R.Bosotti, R.Perego, L.Rusconi, S.Toma, M.Zamai, O.Acuto, and A.Isacchi (2000).
Activation of Zap-70 tyrosine kinase due to a structural rearrangement induced by tyrosine phosphorylation and/or ITAM binding.
  Biochemistry, 39, 2784-2791.  
11085181 H.Jacobs (2000).
TCR-independent T cell development mediated by gain-of-oncogene function or loss-of-tumor-suppressor gene function.
  Semin Immunol, 12, 487-502.  
10666241 L.Bouhdoud, P.Villain, A.Merzouki, M.Arella, and C.Couture (2000).
T-cell receptor-mediated anergy of a human immunodeficiency virus (HIV) gp120-specific CD4(+) cytotoxic T-cell clone, induced by a natural HIV type 1 variant peptide.
  J Virol, 74, 2121-2130.  
10892729 M.Heller, D.R.Goodlett, J.D.Watts, and R.Aebersold (2000).
A comprehensive characterization of the T-cell antigen receptor complex composition by microcapillary liquid chromatography-tandem mass spectrometry.
  Electrophoresis, 21, 2180-2195.  
  10752619 R.O'Brien, P.Rugman, D.Renzoni, M.Layton, R.Handa, K.Hilyard, M.D.Waterfield, P.C.Driscoll, and J.E.Ladbury (2000).
Alternative modes of binding of proteins with tandem SH2 domains.
  Protein Sci, 9, 570-579.  
10681522 R.Zhao, and Z.J.Zhao (2000).
Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs.
  J Biol Chem, 275, 5453-5459.  
10506191 A.F.Giusti, D.J.Carroll, Y.A.Abassi, M.Terasaki, K.R.Foltz, and L.A.Jaffe (1999).
Requirement of a Src family kinase for initiating calcium release at fertilization in starfish eggs.
  J Biol Chem, 274, 29318-29322.  
10195419 C.T.Baldari, and J.L.Telford (1999).
Lymphocyte antigen receptor signal integration and regulation by the SHC adaptor.
  Biol Chem, 380, 129-134.  
10587353 E.N.Kersh, G.J.Kersh, and P.M.Allen (1999).
Partially phosphorylated T cell receptor zeta molecules can inhibit T cell activation.
  J Exp Med, 190, 1627-1636.  
10583414 G.Magistrelli, R.Bosotti, B.Valsasina, C.Visco, R.Perego, S.Toma, O.Acuto, and A.Isacchi (1999).
Role of the Src homology 2 domains and interdomain regions in ZAP-70 phosphorylation and enzymatic activity.
  Eur J Biochem, 266, 1166-1173.  
10318843 M.Pelosi, V.Di Bartolo, V.Mounier, D.Mège, J.M.Pascussi, E.Dufour, A.Blondel, and O.Acuto (1999).
Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck.
  J Biol Chem, 274, 14229-14237.  
9885244 N.Kioka, S.Sakata, T.Kawauchi, T.Amachi, S.K.Akiyama, K.Okazaki, C.Yaen, K.M.Yamada, and S.Aota (1999).
Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization.
  J Cell Biol, 144, 59-69.  
  9858619 Q.Zhao, B.L.Williams, R.T.Abraham, and A.Weiss (1999).
Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes.
  Mol Cell Biol, 19, 948-956.  
10398925 R.A.Grucza, J.M.Bradshaw, K.Fütterer, and G.Waksman (1999).
SH2 domains: from structure to energetics, a dual approach to the study of structure-function relationships.
  Med Res Rev, 19, 273-293.  
10358766 R.N.Germain, and I.Stefanová (1999).
The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation.
  Annu Rev Immunol, 17, 467-522.  
10574909 S.Matsuda, T.Suzuki-Fujimoto, A.Minowa, H.Ueno, K.Katamura, and S.Koyasu (1999).
Temperature-sensitive ZAP70 mutants degrading through a proteasome-independent pathway. Restoration of a kinase domain mutant by Cdc37.
  J Biol Chem, 274, 34515-34518.  
10358768 T.Kurosaki (1999).
Genetic analysis of B cell antigen receptor signaling.
  Annu Rev Immunol, 17, 555-592.  
10037717 V.Di Bartolo, D.Mège, V.Germain, M.Pelosi, E.Dufour, F.Michel, G.Magistrelli, A.Isacchi, and O.Acuto (1999).
Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling.
  J Biol Chem, 274, 6285-6294.  
  9488454 B.L.Williams, K.L.Schreiber, W.Zhang, R.L.Wange, L.E.Samelson, P.J.Leibson, and R.T.Abraham (1998).
Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line.
  Mol Cell Biol, 18, 1388-1399.  
9850860 D.H.Chu, C.T.Morita, and A.Weiss (1998).
The Syk family of protein tyrosine kinases in T-cell activation and development.
  Immunol Rev, 165, 167-180.  
9422724 E.A.Ottinger, M.C.Botfield, and S.E.Shoelson (1998).
Tandem SH2 domains confer high specificity in tyrosine kinase signaling.
  J Biol Chem, 273, 729-735.  
9852069 E.Tomasello, L.Olcese, F.Vély, C.Geourgeon, M.Bléry, A.Moqrich, D.Gautheret, M.Djabali, M.G.Mattei, and E.Vivier (1998).
Gene structure, expression pattern, and biological activity of mouse killer cell activating receptor-associated protein (KARAP)/DAP-12.
  J Biol Chem, 273, 34115-34119.  
9702923 I.Scotese, L.Gaetaniello, G.Matarese, M.Lecora, L.Racioppi, and C.Pignata (1998).
T cell activation deficiency associated with an aberrant pattern of protein tyrosine phosphorylation after CD3 perturbation in Down's syndrome.
  Pediatr Res, 44, 252-258.  
9813084 J.Sloan-Lancaster, J.Presley, J.Ellenberg, T.Yamazaki, J.Lippincott-Schwartz, and L.E.Samelson (1998).
ZAP-70 association with T cell receptor zeta (TCRzeta): fluorescence imaging of dynamic changes upon cellular stimulation.
  J Cell Biol, 143, 613-624.  
9535874 L.Grazioli, V.Germain, A.Weiss, and O.Acuto (1998).
Anti-peptide antibodies detect conformational changes of the inter-SH2 domain of ZAP-70 due to binding to the zeta chain and to intramolecular interactions.
  J Biol Chem, 273, 8916-8921.  
9918123 P.R.Young (1998).
Pharmacological modulation of cytokine action and production through signaling pathways.
  Cytokine Growth Factor Rev, 9, 239-257.  
9732296 R.D.Soede, Y.M.Wijnands, I.Van Kouteren-Cobzaru, and E.Roos (1998).
ZAP-70 tyrosine kinase is required for LFA-1-dependent T cell migration.
  J Cell Biol, 142, 1371-1379.  
9685404 S.Pacini, C.Ulivieri, M.M.Di Somma, A.Isacchi, L.Lanfrancone, P.G.Pelicci, J.L.Telford, and C.T.Baldari (1998).
Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation.
  J Biol Chem, 273, 20487-20493.  
9817027 T.K.Sawyer (1998).
Src homology-2 domains: structure, mechanisms, and drug discovery.
  Biopolymers, 47, 243-261.  
9857070 V.L.Ott, and A.C.Rapraeger (1998).
Tyrosine phosphorylation of syndecan-1 and -4 cytoplasmic domains in adherent B82 fibroblasts.
  J Biol Chem, 273, 35291-35298.  
9700515 Z.Weng, and C.DeLisi (1998).
Toward a predictive understanding of molecular recognition.
  Immunol Rev, 163, 251-266.  
9287188 A.M.Cheng, and A.C.Chan (1997).
Protein tyrosine kinases in thymocyte development.
  Curr Opin Immunol, 9, 528-533.  
9382891 B.T.Bäckström, B.T.Hausmann, and E.Palmer (1997).
Signaling efficiency of the T cell receptor controlled by a single amino acid in the beta chain constant region.
  J Exp Med, 186, 1933-1938.  
9312087 D.E.Jackson, K.R.Kupcho, and P.J.Newman (1997).
Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of platelet/endothelial cell adhesion molecule-1 (PECAM-1) that are required for the cellular association and activation of the protein-tyrosine phosphatase, SHP-2.
  J Biol Chem, 272, 24868-24875.  
9069257 D.Qian, and A.Weiss (1997).
T cell antigen receptor signal transduction.
  Curr Opin Cell Biol, 9, 205-212.  
9394831 F.Vély, J.A.Nunès, B.Malissen, and C.J.Hedgecock (1997).
Analysis of immunoreceptor tyrosine-based activation motif (ITAM) binding to ZAP-70 by surface plasmon resonance.
  Eur J Immunol, 27, 3010-3014.  
9312021 I.A.Graef, L.J.Holsinger, S.Diver, S.L.Schreiber, and G.R.Crabtree (1997).
Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70.
  EMBO J, 16, 5618-5628.  
9143693 J.B.Bolen, and J.S.Brugge (1997).
Leukocyte protein tyrosine kinases: potential targets for drug discovery.
  Annu Rev Immunol, 15, 371-404.  
9241420 J.Kuriyan, and D.Cowburn (1997).
Modular peptide recognition domains in eukaryotic signaling.
  Annu Rev Biophys Biomol Struct, 26, 259-288.  
9388260 K.Sagawa, T.Kimura, M.Swieter, and R.P.Siraganian (1997).
The protein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31).
  J Biol Chem, 272, 31086-31091.  
9099676 L.M.Keshvara, C.Isaacson, M.L.Harrison, and R.L.Geahlen (1997).
Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130.
  J Biol Chem, 272, 10377-10381.  
9143696 M.Reth, and J.Wienands (1997).
Initiation and processing of signals from the B cell antigen receptor.
  Annu Rev Immunol, 15, 453-479.  
9048210 N.Isakov (1997).
ITIMs and ITAMs. The Yin and Yang of antigen and Fc receptor-linked signaling machinery.
  Immunol Res, 16, 85.  
9174343 P.S.Charifson, L.M.Shewchuk, W.Rocque, C.W.Hummel, S.R.Jordan, C.Mohr, G.J.Pacofsky, M.R.Peel, M.Rodriguez, D.D.Sternbach, and T.G.Consler (1997).
Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
  Biochemistry, 36, 6283-6293.
PDB codes: 1a07 1a08 1a09 1a1a 1a1b 1a1c 1a1e
9295038 R.Sunder-Plassmann, F.Lialios, M.Madsen, S.Koyasu, and E.L.Reinherz (1997).
Functional analysis of immunoreceptor tyrosine-based activation motif (ITAM)-mediated signal transduction: the two YxxL segments within a single CD3zeta-ITAM are functionally distinct.
  Eur J Immunol, 27, 2001-2009.  
9667855 S.E.Shoelson (1997).
SH2 and PTB domain interactions in tyrosine kinase signal transduction.
  Curr Opin Chem Biol, 1, 227-234.  
9351806 T.D.Mulhern, G.L.Shaw, C.J.Morton, A.J.Day, and I.D.Campbell (1997).
The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity.
  Structure, 5, 1313-1323.
PDB codes: 1aot 1aou
9203415 T.Kurosaki (1997).
Molecular mechanisms in B cell antigen receptor signaling.
  Curr Opin Immunol, 9, 309-318.  
9053397 W.D.Kohn, C.T.Mant, and R.S.Hodges (1997).
Alpha-helical protein assembly motifs.
  J Biol Chem, 272, 2583-2586.  
8794001 A.C.Chan, and A.S.Shaw (1996).
Regulation of antigen receptor signal transduction by protein tyrosine kinases.
  Curr Opin Immunol, 8, 394-401.  
  8670861 A.L.Breeze, B.V.Kara, D.G.Barratt, M.Anderson, J.C.Smith, R.W.Luke, J.R.Best, and S.A.Cartlidge (1996).
Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase.
  EMBO J, 15, 3579-3589.
PDB code: 1pic
8691146 A.M.Fry, L.L.Lanier, and A.Weiss (1996).
Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C.
  J Exp Med, 184, 295-300.  
9010718 C.A.Chambers, M.F.Krummel, B.Boitel, A.Hurwitz, T.J.Sullivan, S.Fournier, D.Cassell, M.Brunner, and J.P.Allison (1996).
The role of CTLA-4 in the regulation and initiation of T-cell responses.
  Immunol Rev, 153, 27-46.  
8729452 D.H.Fremont, W.A.Rees, and H.Kozono (1996).
Biophysical studies of T-cell receptors and their ligands.
  Curr Opin Immunol, 8, 93.  
8805596 H.J.Nam, W.G.Haser, T.M.Roberts, and C.A.Frederick (1996).
Intramolecular interactions of the regulatory domains of the Bcr-Abl kinase reveal a novel control mechanism.
  Structure, 4, 1105-1114.
PDB code: 2abl
8810330 H.Ohnishi, M.Kubota, A.Ohtake, K.Sato, and S.Sano (1996).
Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule.
  J Biol Chem, 271, 25569-25574.  
8784353 J.A.Grobler, L.O.Essen, R.L.Williams, and J.H.Hurley (1996).
C2 domain conformational changes in phospholipase C-delta 1.
  Nat Struct Biol, 3, 788-795.
PDB codes: 1qas 1qat
8780508 J.E.Ladbury, M.Hensmann, G.Panayotou, and I.D.Campbell (1996).
Alternative modes of tyrosyl phosphopeptide binding to a Src family SH2 domain: implications for regulation of tyrosine kinase activity.
  Biochemistry, 35, 11062-11069.  
8673601 J.Rahuel, B.Gay, D.Erdmann, A.Strauss, C.Garcia-Echeverría, P.Furet, G.Caravatti, H.Fretz, J.Schoepfer, and M.G.Grütter (1996).
Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode.
  Nat Struct Biol, 3, 586-589.
PDB code: 1tze
9064347 K.B.Bacon, M.C.Szabo, H.Yssel, J.B.Bolen, and T.J.Schall (1996).
RANTES induces tyrosine kinase activity of stably complexed p125FAK and ZAP-70 in human T cells.
  J Exp Med, 184, 873-882.  
8794005 L.D.Notarangelo (1996).
Immunodeficiencies caused by genetic defects in protein kinases.
  Curr Opin Immunol, 8, 448-453.  
8814252 M.Thome, V.Germain, J.P.DiSanto, and O.Acuto (1996).
The p56lck SH2 domain mediates recruitment of CD8/p56lck to the activated T cell receptor/CD3/zeta complex.
  Eur J Immunol, 26, 2093-2100.  
8642247 N.S.van Oers, N.Killeen, and A.Weiss (1996).
Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.
  J Exp Med, 183, 1053-1062.  
8901551 P.V.LoGrasso, J.Hawkins, L.J.Frank, D.Wisniewski, and A.Marcy (1996).
Mechanism of activation for Zap-70 catalytic activity.
  Proc Natl Acad Sci U S A, 93, 12165-12170.  
  8943331 Q.Zhao, and A.Weiss (1996).
Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.
  Mol Cell Biol, 16, 6765-6774.  
8599763 R.T.Nolte, M.J.Eck, J.Schlessinger, S.E.Shoelson, and S.C.Harrison (1996).
Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes.
  Nat Struct Biol, 3, 364-374.
PDB codes: 2iug 2iuh 2iui
  8943371 S.Yamasaki, M.Takamatsu, and M.Iwashima (1996).
The kinase, SH3, and SH2 domains of Lck play critical roles in T-cell activation after ZAP-70 membrane localization.
  Mol Cell Biol, 16, 7151-7160.  
8810294 T.Chen, B.Repetto, R.Chizzonite, C.Pullar, C.Burghardt, E.Dharm, Z.Zhao, R.Carroll, P.Nunes, M.Basu, W.Danho, M.Visnick, J.Kochan, D.Waugh, and A.M.Gilfillan (1996).
Interaction of phosphorylated FcepsilonRIgamma immunoglobulin receptor tyrosine activation motif-based peptides with dual and single SH2 domains of p72syk. Assessment of binding parameters and real time binding kinetics.
  J Biol Chem, 271, 25308-25315.  
8673454 T.J.Wandless (1996).
SH2 domains: a question of independence.
  Curr Biol, 6, 125-127.  
8910399 T.Kimura, H.Kihara, S.Bhattacharyya, H.Sakamoto, E.Appella, and R.P.Siraganian (1996).
Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor.
  J Biol Chem, 271, 27962-27968.  
8952511 U.L.Günther, Y.Liu, D.Sanford, W.W.Bachovchin, and B.Schaffhausen (1996).
NMR analysis of interactions of a phosphatidylinositol 3'-kinase SH2 domain with phosphotyrosine peptides reveals interdependence of major binding sites.
  Biochemistry, 35, 15570-15581.  
8760790 V.A.Boussiotis, D.L.Barber, B.J.Lee, J.G.Gribben, G.J.Freeman, and L.M.Nadler (1996).
Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation.
  J Exp Med, 184, 365-376.  
8805558 W.A.Lim (1996).
Reading between the lines: SH3 recognition of an intact protein.
  Structure, 4, 657-659.  
8681956 W.Weissenhorn, M.J.Eck, S.C.Harrison, and D.C.Wiley (1996).
Phosphorylated T cell receptor zeta-chain and ZAP70 tandem SH2 domains form a 1:3 complex in vitro.
  Eur J Biochem, 238, 440-445.  
8590006 B.J.Mayer (1995).
Why two heads are better.
  Structure, 3, 977-980.  
8590001 S.S.Narula, R.W.Yuan, S.E.Adams, O.M.Green, J.Green, T.B.Philips, L.D.Zydowsky, M.C.Botfield, M.Hatada, and E.R.Laird (1995).
Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide.
  Structure, 3, 1061-1073.
PDB codes: 1csy 1csz
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

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