PDBsum entry 2op7

Ligase

PDB id: 2op7

Contents

Protein chain

39 a.a. *

* Residue conservation analysis

PDB id:

2op7

Name:

Ligase

Title:

Ww4

Structure:

Nedd4-like e3 ubiquitin-protein ligase wwp1. Chain: a. Fragment: residues 494-532. Synonym: ww domain- containing protein 1, atropin-1-interacting protein 5, aip5. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: wwp1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.

NMR struc:

10 models

Authors:

H.N.Qin,M.F.Li,H.Pu,S.Sankaran,S.Ahmed,J.X.Song

Key ref:

H.N.Qin et al. Nmr structure of the forth ww domain of wwp1. To be published, .

Date:

27-Jan-07 Release date: 11-Dec-07

Protein chain

Q9H0M0  (WWP1_HUMAN) -  NEDD4-like E3 ubiquitin-protein ligase WWP1 from Homo sapiens

Seq: 922 a.a.

Struc: 39 a.a.

Enzyme reactions

• Enzyme class: E.C.2.3.2.26 - HECT-type E3 ubiquitin transferase.
• Reaction: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆- ubiquitinyl-[acceptor protein]-L-lysine