UniProt functional annotation for P05091

UniProt code: P05091.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
 
Catalytic activity: An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
Pathway: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Subunit: Homotetramer.
Subcellular location: Mitochondrion matrix.
Polymorphism: Genetic variation in ALDH2 is responsible for individual differences in responses to drinking alcohol [MIM:610251]. Allele ALDH2*2 is associated with a very high incidence of acute alcohol intoxication in Orientals and South American Indians, as compared to Caucasians.
Similarity: Belongs to the aldehyde dehydrogenase family.
Sequence caution: Sequence=AAA62825.1; Type=Frameshift; Positions=424, 444, 448, 461; Sequence=CAA68290.1; Type=Frameshift; Positions=Several; Sequence=CAA68290.1; Type=Miscellaneous discrepancy;

Annotations taken from UniProtKB at the EBI.