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UniProt functional annotation for Q99T13 | ||
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| UniProt code: Q99T13. |
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| Organism: | |
Staphylococcus aureus (strain Mu50 / ATCC 700699). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae; Staphylococcus. |
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| Function: | |
May be involved in multidrug export. Transmembrane domains (TMD) form a pore in the cell membrane and the ATP-binding domain (NBD) is responsible for energy generation. {ECO:0000269|PubMed:16943773}. |
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| Activity regulation: | |
ATPase activity is inhibited by orthovanadate and activated by the cancer drugs doxorubicin and vinblastine. {ECO:0000269|PubMed:16943773}. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:16943773}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:16943773}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:16943773}. |
| Domain: | |
The ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused. |
| Similarity: | |
Belongs to the ABC transporter superfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.