PDBsum entry 2ojg

Transferase

PDB id: 2ojg

Contents

Protein chain

337 a.a.

Ligands

SO4

19A

Waters ×188

References listed in PDB file

Key reference

• Title: Flipped out: structure-Guided design of selective pyrazolylpyrrole erk inhibitors.
• Authors: A.M.Aronov, C.Baker, G.W.Bemis, J.Cao, G.Chen, P.J.Ford, U.A.Germann, J.Green, M.R.Hale, M.Jacobs, J.W.Janetka, F.Maltais, G.Martinez-Botella, M.N.Namchuk, J.Straub, Q.Tang, X.Xie.
• Ref.: J Med Chem, 2007, 50, 1280-1287. [DOI no: 10.1021/jm061381f]
• PubMed id: 17300186

Abstract

The Ras/Raf/MEK/ERK signal transduction is a key oncogenic pathway implicated in a variety of human cancers. We have identified a novel series of pyrazolylpyrroles as inhibitors of ERK. Aided by the discovery of two distinct binding modes for the pyrazolylpyrrole scaffold, structure-guided optimization culminated in the discovery of 6p, a potent and selective inhibitor of ERK.