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UniProt functional annotation for P49796 | ||
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| UniProt code: P49796. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein- mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
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| Subunit: | |
Binds EFNB1 and EFNB2 (By similarity). Binds the GNB1-GNG2 heterodimer. {ECO:0000250}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:9858594}. Nucleus {ECO:0000269|PubMed:10749886}. Cell membrane {ECO:0000269|PubMed:9858594}; Peripheral membrane protein {ECO:0000269|PubMed:9858594}. Note=Long isoforms are cytoplasmic and associated with the plasma membrane (PubMed:9858594). Short isoforms are nuclear (PubMed:10749886). |
| Ptm: | |
Phosphorylated by cyclic GMP-dependent protein kinase. {ECO:0000250}. |
| Ptm: | |
ISGylated. {ECO:0000305|PubMed:16884686}. |
| Miscellaneous: | |
[Isoform 2]: Nuclear. {ECO:0000269|PubMed:10749886}. |
Annotations taken from UniProtKB at the EBI.