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UniProt functional annotation for Q9ZGH4 | ||
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| UniProt code: Q9ZGH4. |
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| Organism: | |
Streptomyces venezuelae. |
| Taxonomy: | |
Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces. |
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| Function: | |
Involved in the biosynthesis of dTDP-alpha-D-desosamine, a sugar found in several bacterial macrolide antibiotics. Catalyzes the reversible transfer of the amino group from L-glutamate to the C-3 position of dTDP-3-keto-4,6-deoxyglucose to yield dTDP-3-amino-3,4,6- trideoxyglucose. {ECO:0000305|PubMed:17456741}. |
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| Catalytic activity: | |
Reaction=2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose = dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate; Xref=Rhea:RHEA:39907, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:63262, ChEBI:CHEBI:76280; EC=2.6.1.106; Evidence={ECO:0000305|PubMed:17456741}; |
| Cofactor: | |
Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000269|PubMed:17456741}; |
| Pathway: | |
Antibiotic biosynthesis. {ECO:0000305}. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:17456741}. |
| Similarity: | |
Belongs to the degT/dnrJ/eryC1 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.