UniProt functional annotation for P57771



	UniProt functional annotation for P57771

UniProt code: P57771.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity). {ECO:0000250|UniProtKB:P49804, ECO:0000269|PubMed:18434541}.

Subunit: Interacts with GNAO1 (By similarity). Interacts with GNAI3. {ECO:0000250|UniProtKB:P49804, ECO:0000269|PubMed:18434541}.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P49804}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49804}; Cytoplasmic side {ECO:0000250|UniProtKB:P49804}. Membrane {ECO:0000250|UniProtKB:P49804}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49804}; Cytoplasmic side {ECO:0000250|UniProtKB:P49804}. Perikaryon {ECO:0000250|UniProtKB:P49804}. Cell projection, dendrite {ECO:0000250|UniProtKB:P49804}. Nucleus {ECO:0000250|UniProtKB:P49804}. Note=Detected in Purkinje cell soma and dendrites. Associated with Purkinje cell membranes. Not detected in Purkinje cell nuclei. Detected in the nucleus after heterologous expression. Recruited to the cell membrane in the presence of GNAO1. {ECO:0000250|UniProtKB:P49804}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity). {ECO:0000250\|UniProtKB:P49804, ECO:0000269\|PubMed:18434541}.


Subunit:		Interacts with GNAO1 (By similarity). Interacts with GNAI3. {ECO:0000250\|UniProtKB:P49804, ECO:0000269\|PubMed:18434541}.
Subcellular location:		Cell membrane {ECO:0000250\|UniProtKB:P49804}; Peripheral membrane protein {ECO:0000250\|UniProtKB:P49804}; Cytoplasmic side {ECO:0000250\|UniProtKB:P49804}. Membrane {ECO:0000250\|UniProtKB:P49804}; Peripheral membrane protein {ECO:0000250\|UniProtKB:P49804}; Cytoplasmic side {ECO:0000250\|UniProtKB:P49804}. Perikaryon {ECO:0000250\|UniProtKB:P49804}. Cell projection, dendrite {ECO:0000250\|UniProtKB:P49804}. Nucleus {ECO:0000250\|UniProtKB:P49804}. Note=Detected in Purkinje cell soma and dendrites. Associated with Purkinje cell membranes. Not detected in Purkinje cell nuclei. Detected in the nucleus after heterologous expression. Recruited to the cell membrane in the presence of GNAO1. {ECO:0000250\|UniProtKB:P49804}.