PDBsum entry 2o8t

Hydrolase

PDB id

2o8t

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Contents

			Protein chain

					231 a.a. *

			Ligands

					SO4 ×2


					1PE ×2


					PEG

			Waters ×220

* Residue conservation analysis

PDB id:

2o8t

Links
- PDBe
- RCSB
- MMDB
- JenaLib
- Proteopedia
- CATH
- SCOP
- PDBSWS
- PDBePISA
- CSA
- ProSAT

Name:

Hydrolase

Title:

Crystal structure and binding epitopes of urokinase-type plasminogen activator (c122a/n145q) in complex with inhibitors

Structure:

Urokinase plasminogen activator. Chain: a. Fragment: residues 16-250 (159-411). Synonym: upa. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922.

Resolution:

1.45Å

R-factor:

0.242

R-free:

0.265

Authors:

G.Zhao,C.Yuan,L.Jiang,Z.Huang,M.Huang

Date:

12-Dec-06

Release date:

25-Dec-07

PROCHECK

	Headers

	References

Protein chain

P00749 (UROK_HUMAN) - Urokinase-type plasminogen activator from Homo sapiens

Seq: Struc:					431 a.a. 231 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 2 residue positions (black crosses)



		Enzyme reactions

Enzyme class:

E.C.3.4.21.73 - u-plasminogen activator.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.