UniProt functional annotation for P35774



	UniProt functional annotation for P35774

UniProt code: P35774.

Organism: Human adenovirus B serotype 11 (strain Slobiski) (HAdV-11) (Human adenovirus 11P (strain Slobiski)).

Taxonomy: Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes; Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus B.

Function: Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CD46 to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface.

Subunit: Homotrimer. Interacts with host receptor CD46. Interacts (via N-terminal tail region) with pentons (By similarity). {ECO:0000250}.

Subcellular location: Virion {ECO:0000250}. Host nucleus {ECO:0000250}. Note=Anchored to the pentons, protrudes from the virion surface. {ECO:0000250}.

Induction: Expressed in the late phase of the viral replicative cycle.

Domain: The tail region anchors the fiber to penton base capsomers, whereas the shaft, built from several repeated motifs, allows the knob to protrude from the virion. {ECO:0000250}.

Miscellaneous: All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell (By similarity). {ECO:0000250}.

Similarity: Belongs to the adenoviridae fiber family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Human adenovirus B serotype 11 (strain Slobiski) (HAdV-11) (Human adenovirus 11P (strain Slobiski)).
Taxonomy:		Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes; Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus B.



Function:		Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CD46 to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface.


Subunit:		Homotrimer. Interacts with host receptor CD46. Interacts (via N-terminal tail region) with pentons (By similarity). {ECO:0000250}.
Subcellular location:		Virion {ECO:0000250}. Host nucleus {ECO:0000250}. Note=Anchored to the pentons, protrudes from the virion surface. {ECO:0000250}.
Induction:		Expressed in the late phase of the viral replicative cycle.
Domain:		The tail region anchors the fiber to penton base capsomers, whereas the shaft, built from several repeated motifs, allows the knob to protrude from the virion. {ECO:0000250}.
Miscellaneous:		All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell (By similarity). {ECO:0000250}.
Similarity:		Belongs to the adenoviridae fiber family. {ECO:0000305}.