UniProt functional annotation for Q15059



	UniProt functional annotation for Q15059

UniProt code: Q15059.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:18406326, PubMed:27105114). Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). {ECO:0000250|UniProtKB:Q8K2F0, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:27105114}.

Subunit: Interacts (via bromo domain 1) with GATA1 acetylated at 'Lys- 312' and 'Lys-315'. Interacts (via bromo domain 1) with GATA2 acetylated on lysine residues (By similarity). Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (in vitro). {ECO:0000250|UniProtKB:Q8K2F0, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:22464331}.

Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8K2F0}. Note=Detected on chromatin. {ECO:0000250|UniProtKB:Q8K2F0}.

Tissue specificity: Ubiquitous.

Domain: The Bromo domains specifically recognize and bind acetylated histones. {ECO:0000269|PubMed:27105114}.

Disease: Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUTM1 which produces a BRD3-NUTM1 fusion protein. {ECO:0000269|PubMed:17934517}.

Sequence caution: Sequence=BAA05393.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:18406326, PubMed:27105114). Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). {ECO:0000250\|UniProtKB:Q8K2F0, ECO:0000269\|PubMed:18406326, ECO:0000269\|PubMed:27105114}.


Subunit:		Interacts (via bromo domain 1) with GATA1 acetylated at 'Lys- 312' and 'Lys-315'. Interacts (via bromo domain 1) with GATA2 acetylated on lysine residues (By similarity). Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (in vitro). {ECO:0000250\|UniProtKB:Q8K2F0, ECO:0000269\|PubMed:18406326, ECO:0000269\|PubMed:22464331}.
Subcellular location:		Nucleus {ECO:0000250\|UniProtKB:Q8K2F0}. Note=Detected on chromatin. {ECO:0000250\|UniProtKB:Q8K2F0}.
Tissue specificity:		Ubiquitous.
Domain:		The Bromo domains specifically recognize and bind acetylated histones. {ECO:0000269\|PubMed:27105114}.
Disease:		Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUTM1 which produces a BRD3-NUTM1 fusion protein. {ECO:0000269\|PubMed:17934517}.
Sequence caution:		Sequence=BAA05393.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};