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PDBsum entry 2nxb
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protein ligands metals Protein-protein interface(s) links
Signaling protein PDB id
2nxb

 

 

 

 

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Contents
Protein chains
111 a.a. *
121 a.a. *
Ligands
EDO ×7
Metals
_NA
Waters ×278
* Residue conservation analysis
PDB id:
2nxb
Name: Signaling protein
Title: Crystal structure of human bromodomain containing protein 3 (brd3)
Structure: Bromodomain-containing protein 3. Chain: a, b. Fragment: bromo 1 domain. Synonym: ring3-like protein. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: brd3, kiaa0043, ring3l. Expressed in: escherichia coli. Expression_system_taxid: 562.
Biol. unit: Dimer (from PQS)
Resolution:
1.40Å     R-factor:   0.168     R-free:   0.185
Authors: P.Filippakopoulos,A.Bullock,C.Cooper,K.Keates,G.Berridge,A.Pike, G.Bunkoczi,A.Edwards,C.Arrowsmith,M.Sundstrom,F.Von Delft,S.Knapp, Structural Genomics Consortium (Sgc)
Key ref: P.Filippakopoulos et al. (2012). Histone recognition and large-scale structural analysis of the human bromodomain family. Cell, 149, 214-231. PubMed id: 22464331
Date:
17-Nov-06     Release date:   12-Dec-06    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q15059  (BRD3_HUMAN) -  Bromodomain-containing protein 3 from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		726 a.a.
111 a.a.
Protein chain
Pfam   ArchSchema ?
Q15059  (BRD3_HUMAN) -  Bromodomain-containing protein 3 from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		726 a.a.
121 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 

 
Cell 149:214-231 (2012)
PubMed id: 22464331  
 
 
Histone recognition and large-scale structural analysis of the human bromodomain family.
P.Filippakopoulos, S.Picaud, M.Mangos, T.Keates, J.P.Lambert, D.Barsyte-Lovejoy, I.Felletar, R.Volkmer, S.Müller, T.Pawson, A.C.Gingras, C.H.Arrowsmith, S.Knapp.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23211769 C.A.Musselman, M.E.Lalonde, J.Côté, and T.G.Kutateladze (2012).
Perceiving the epigenetic landscape through histone readers.
  Nat Struct Mol Biol, 19, 1218-1227.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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