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UniProt functional annotation for P0A6C1 | ||
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| UniProt code: P0A6C1. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. |
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| Catalytic activity: | |
Reaction=Endonucleolytic cleavage to 5'-phosphooligonucleotide end- products.; EC=3.1.21.2; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 3 Zn(2+) ions. Can also bind Mn(2+) ions.; |
| Subunit: | |
Monomer. |
| Induction: | |
Endonuclease IV is induced by agents which generate superoxide radical anions. |
| Similarity: | |
Belongs to the AP endonuclease 2 family. {ECO:0000255|HAMAP-Rule:MF_00152, ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.