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PDBsum entry 2npl
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Cell adhesion
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PDB id
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2npl
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References listed in PDB file
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Key reference
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Title
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Solution structure of the coxsackievirus and adenovirus receptor domain 2.
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Authors
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S.Jiang,
M.Caffrey.
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Ref.
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Protein Sci, 2007,
16,
539-542.
[DOI no: ]
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PubMed id
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Abstract
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The coxsackievirus and adenovirus receptor (CAR) mediates entry of
coxsackievirus and adenovirus. CAR possesses an extracellular region that is
comprised of 2 immunoglobulin domains termed CAR-D1 and CAR-D2. In the present
work, the solution structure of CAR-D2, consisting of residues 142-235 of human
CAR, has been determined by NMR spectroscopy. CAR-D2 is shown to be a
beta-sandwich motif comprised of two beta-sheets, which are stabilized by two
disulfide bonds. The first beta-sheet is comprised of beta-strands A, B, and E,
and the second beta-sheet is comprised of beta-strands C, F, and G. A relatively
hydrophobic helix is found between beta-strands C and E, which replaces
beta-strand D of the classical c-type immunoglobulin fold.
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Figure 2.
Figure 2. Model for the mechanism of CAR. The CAR--D1 domains are colored blue and green and the CAR--D2 domains are colored
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The above figure is
reprinted
by permission from the Protein Society:
Protein Sci
(2007,
16,
539-542)
copyright 2007.
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