PDBsum entry 2npl

Cell adhesion

PDB id

2npl

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Contents

			Protein chain

					96 a.a. *

* Residue conservation analysis

PDB id:

2npl

Links
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- MMDB
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- Proteopedia
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- ProSAT

Name:

Cell adhesion

Title:

Nmr structure of card d2 domain

Structure:

Coxsackievirus and adenovirus receptor. Chain: x. Fragment: domain car 2. Synonym: coxsackievirus b- adenovirus receptor. Hcar. Cvb3-binding protein. Hcvadr. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cxadr, car. Expressed in: escherichia coli. Expression_system_taxid: 562.

NMR struc:

1 models

Authors:

S.Jiang,M.Caffrey

Key ref:

S.Jiang and M.Caffrey (2007). Solution structure of the coxsackievirus and adenovirus receptor domain 2. Protein Sci, 16, 539-542. PubMed id: 17322536 DOI: 10.1110/ps.062643507

Date:

27-Oct-06

Release date:

13-Mar-07

PROCHECK

	Headers

	References

Protein chain

P78310 (CXAR_HUMAN) - Coxsackievirus and adenovirus receptor from Homo sapiens

Seq: Struc:					365 a.a. 96 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

DOI no: 10.1110/ps.062643507	Protein Sci 16:539-542 (2007)
PubMed id: 17322536

Solution structure of the coxsackievirus and adenovirus receptor domain 2.
S.Jiang, M.Caffrey.

ABSTRACT

The coxsackievirus and adenovirus receptor (CAR) mediates entry of coxsackievirus and adenovirus. CAR possesses an extracellular region that is comprised of 2 immunoglobulin domains termed CAR-D1 and CAR-D2. In the present work, the solution structure of CAR-D2, consisting of residues 142-235 of human CAR, has been determined by NMR spectroscopy. CAR-D2 is shown to be a beta-sandwich motif comprised of two beta-sheets, which are stabilized by two disulfide bonds. The first beta-sheet is comprised of beta-strands A, B, and E, and the second beta-sheet is comprised of beta-strands C, F, and G. A relatively hydrophobic helix is found between beta-strands C and E, which replaces beta-strand D of the classical c-type immunoglobulin fold.

Selected figure(s)



	Figure 2. Figure 2. Model for the mechanism of CAR. The CAR--D1 domains are colored blue and green and the CAR--D2 domains are colored

Figure was selected by an automated process.

Literature references that cite this PDB file's key reference

PubMed id

Reference

20813955

P.Verdino, D.A.Witherden, W.L.Havran, and I.A.Wilson (2010).
The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K.

Science, 329, 1210-1214.

PDB codes:

3mj6 3mj7

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.