UniProt functional annotation for P18573

UniProt code: P18573.

Organism: Triticum aestivum (Wheat).
Taxonomy: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade; Pooideae; Triticeae; Triticum.
 
Function: Gliadin is the major seed storage protein in wheat.
 
Ptm: Substrate of transglutaminase.
Allergen: Causes an allergic reaction in human. Is the cause of the celiac disease, also known as celiac sprue or gluten-sensitive enteropathy.
Miscellaneous: An internal 33-mer peptide seems to be the primary initiator of the inflammatory response to gluten.
Miscellaneous: The alpha/beta-gliadins can be divided into 5 homology classes. Sequence divergence between the classes is due to single base substitutions and to duplications or deletions within or near direct repeats. There are more than a 100 copies of the gene for alpha/beta-gliadin per haploid genome.
Similarity: Belongs to the gliadin/glutenin family.

Annotations taken from UniProtKB at the EBI.