PDBsum entry 2nll

Transcription/DNA

PDB id: 2nll

Contents

Protein chains

66 a.a. *

103 a.a. *

DNA/RNA

Metals

_ZN ×4

Waters ×236

* Residue conservation analysis

References listed in PDB file

Key reference

• Title: Structural determinants of nuclear receptor assembly on DNA direct repeats.
• Authors: F.Rastinejad, T.Perlmann, R.M.Evans, P.B.Sigler.
• Ref.: Nature, 1995, 375, 203-211.
• PubMed id: 7746322

Abstract

Nuclear receptor heterodimers recognize response elements composed of two direct repeats of the consensus sequence 5'-AGGTCA-3' separated by one to five base pairs. The 1.9 A crystal structure of the complex formed by the DNA-binding domains of the 9-cis retinoic acid receptor and thyroid hormone receptor bound to a thyroid-response element shows that the subunits interact through a DNA-supported interface involving the carboxy-terminal extension of the DNA-binding domain of the thyroid hormone receptor. The stereochemistry suggests a mechanism by which heterodimers recognize the inter-half-site spacing between direct repeats.