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UniProt functional annotation for P60022 | ||
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| UniProt code: P60022. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636). {ECO:0000269|PubMed:25122636}. |
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| Subunit: | |
Monomer (PubMed:23938203). Homodimer (PubMed:23938203). {ECO:0000269|PubMed:23938203}. |
| Subcellular location: | |
Secreted {ECO:0000269|PubMed:7628632}. Membrane {ECO:0000269|PubMed:23938203}. Note=Associates with tumor cell membrane-derived microvesicles (PubMed:23938203). {ECO:0000269|PubMed:23938203}. |
| Tissue specificity: | |
Blood plasma. Sperm. Highly expressed in the lower head and midpiece of sperm. Significantly reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level). {ECO:0000269|PubMed:25122636, ECO:0000269|PubMed:7628632}. |
| Mass spectrometry: | |
Mass=3928; Mass_error=0.5; Method=Electrospray; Evidence={ECO:0000269|PubMed:7628632}; |
| Similarity: | |
Belongs to the beta-defensin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.