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PDBsum entry 2ncm
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Cell adhesion PDB id
2ncm

 

 

 

 

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Contents
Protein chain
99 a.a. *
* Residue conservation analysis
PDB id:
2ncm
Name: Cell adhesion
Title: Neural cell adhesion molecule, nmr, 20 structures
Structure: Neural cell adhesion molecule. Chain: a. Fragment: domain 1. Synonym: ncam domain 1. Engineered: yes
Source: Mus musculus. House mouse. Organism_taxid: 10090. Strain: c57bl/6. Organ: brain. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
NMR struc: 20 models
Authors: N.K.Thomsen,F.M.Poulsen
Key ref: N.K.Thomsen et al. (1996). The three-dimensional structure of the first domain of neural cell adhesion molecule. Nat Struct Biol, 3, 581-585. PubMed id: 8673600
Date:
16-Dec-96     Release date:   12-Mar-97    
Supersedes: 1ncm
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P13595  (NCAM1_MOUSE) -  Neural cell adhesion molecule 1 from Mus musculus
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1115 a.a.
99 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 

 
Nat Struct Biol 3:581-585 (1996)
PubMed id: 8673600  
 
 
The three-dimensional structure of the first domain of neural cell adhesion molecule.
N.K.Thomsen, V.Soroka, P.H.Jensen, V.Berezin, V.V.Kiselyov, E.Bock, F.M.Poulsen.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
20640153 S.Li, E.Bock, and V.Berezin (2010).
Neuritogenic and neuroprotective properties of Peptide agonists of the fibroblast growth factor receptor.
  Int J Mol Sci, 11, 2291-2305.  
19634127 S.Li, C.Christensen, L.B.Køhler, V.V.Kiselyov, V.Berezin, and E.Bock (2009).
Agonists of fibroblast growth factor receptor induce neurite outgrowth and survival of cerebellar granule neurons.
  Dev Neurobiol, 69, 837-854.  
17192269 A.Ababou, M.Gautel, and M.Pfuhl (2007).
Dissecting the N-terminal myosin binding site of human cardiac myosin-binding protein C. Structure and myosin binding of domain C2.
  J Biol Chem, 282, 9204-9215.
PDB code: 1pd6
16467305 X.Dong, F.Xu, Y.Gong, J.Gao, P.Lin, T.Chen, Y.Peng, B.Qiang, J.Yuan, X.Peng, and Z.Rao (2006).
Crystal structure of the V domain of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule.
  J Biol Chem, 281, 10610-10617.
PDB code: 1z9m
16188877 J.A.Wieland, A.A.Gewirth, and D.E.Leckband (2005).
Single molecule adhesion measurements reveal two homophilic neural cell adhesion molecule bonds with mechanically distinct properties.
  J Biol Chem, 280, 41037-41046.  
16045455 V.V.Kiselyov, V.Soroka, V.Berezin, and E.Bock (2005).
Structural biology of NCAM homophilic binding and activation of FGFR.
  J Neurochem, 94, 1169-1179.  
11983682 V.Soroka, D.Kiryushko, V.Novitskaya, L.C.Ronn, F.M.Poulsen, A.Holm, E.Bock, and V.Berezin (2002).
Induction of neuronal differentiation by a peptide corresponding to the homophilic binding site of the second Ig module of the neural cell adhesion molecule.
  J Biol Chem, 277, 24676-24683.  
11160747 C.Xiao, C.M.Bator, V.D.Bowman, E.Rieder, Y.He, B.Hébert, J.Bella, T.S.Baker, E.Wimmer, R.J.Kuhn, and M.G.Rossmann (2001).
Interaction of coxsackievirus A21 with its cellular receptor, ICAM-1.
  J Virol, 75, 2444-2451.  
10820224 A.G.Foley, B.P.Hartz, H.C.Gallagher, L.C.Rønn, V.Berezin, E.Bock, and C.M.Regan (2000).
A synthetic peptide ligand of neural cell adhesion molecule (NCAM) IgI domain prevents NCAM internalization and disrupts passive avoidance learning.
  J Neurochem, 74, 2607-2613.  
10795813 E.Vinogradov, B.O.Petersen, and J.O.Duus (2000).
Isolation and characterization of non-labeled and 13C-labeled mannans from Pichia pastoris yeast.
  Carbohydr Res, 325, 216-221.  
10899941 L.C.Rønn, P.Doherty, A.Holm, V.Berezin, and E.Bock (2000).
Neurite outgrowth induced by a synthetic peptide ligand of neural cell adhesion molecule requires fibroblast growth factor receptor activation.
  J Neurochem, 75, 665-671.  
10398298 G.Skladchikova, L.C.Ronn, V.Berezin, and E.Bock (1999).
Extracellular adenosine triphosphate affects neural cell adhesion molecule (NCAM)-mediated cell adhesion and neurite outgrowth.
  J Neurosci Res, 57, 207-218.  
10338358 R.Probstmeier, and P.Pesheva (1999).
I-type lectins in the nervous system.
  Prog Neurobiol, 58, 163-184.  
9588627 K.C.Breen, C.M.Coughlan, and F.D.Hayes (1998).
The role of glycoproteins in neural development function, and disease.
  Mol Neurobiol, 16, 163-220.  
9242926 C.Chothia, and E.Y.Jones (1997).
The molecular structure of cell adhesion molecules.
  Annu Rev Biochem, 66, 823-862.  
9442878 D.J.Leahy (1997).
Implications of atomic-resolution structures for cell adhesion.
  Annu Rev Cell Dev Biol, 13, 363-393.  
9442880 F.S.Walsh, and P.Doherty (1997).
Neural cell adhesion molecules of the immunoglobulin superfamily: role in axon growth and guidance.
  Annu Rev Cell Dev Biol, 13, 425-456.  
  8947027 A.Bateman, M.Jouet, J.MacFarlane, J.S.Du, S.Kenwrick, and C.Chothia (1996).
Outline structure of the human L1 cell adhesion molecule and the sites where mutations cause neurological disorders.
  EMBO J, 15, 6050-6059.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

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