UniProt functional annotation for P46065



	UniProt functional annotation for P46065

UniProt code: P46065.

Organism: Bos taurus (Bovine).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.

Function: Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (PubMed:7520254, PubMed:8626484, PubMed:9651312, PubMed:26703466). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure (PubMed:7520254, PubMed:8626484). May be involved in cone photoreceptor light response and recovery of response in bright light (By similarity). {ECO:0000250|UniProtKB:P43081, ECO:0000269|PubMed:7520254, ECO:0000269|PubMed:8626484}.

Subunit: Homodimer. {ECO:0000250|UniProtKB:P43080}.

Subcellular location: Membrane; Lipid-anchor {ECO:0000269|PubMed:7520254}. Photoreceptor inner segment {ECO:0000269|PubMed:9620085}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:9620085}. Note=Subcellular location is not affected by light or dark conditions. {ECO:0000250|UniProtKB:P43081}.

Tissue specificity: Detected in the retina (PubMed:7520254). Detected in rod and cone photoreceptor cells (at protein level) (PubMed:8626484, PubMed:9620085). Also present in certain pinealocytes (PubMed:10821676). {ECO:0000269|PubMed:10821676, ECO:0000269|PubMed:7520254, ECO:0000269|PubMed:8626484, ECO:0000269|PubMed:9620085}.

Domain: Binds three calcium ions (via EF-hands 2, 3 and 4) when calcium levels are high. Binds Mg(2+) when calcium levels are low. {ECO:0000269|PubMed:26703466}.

Annotations taken from UniProtKB at the EBI.


Organism:		Bos taurus (Bovine).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.



Function:		Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (PubMed:7520254, PubMed:8626484, PubMed:9651312, PubMed:26703466). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure (PubMed:7520254, PubMed:8626484). May be involved in cone photoreceptor light response and recovery of response in bright light (By similarity). {ECO:0000250\|UniProtKB:P43081, ECO:0000269\|PubMed:7520254, ECO:0000269\|PubMed:8626484}.


Subunit:		Homodimer. {ECO:0000250\|UniProtKB:P43080}.
Subcellular location:		Membrane; Lipid-anchor {ECO:0000269\|PubMed:7520254}. Photoreceptor inner segment {ECO:0000269\|PubMed:9620085}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269\|PubMed:9620085}. Note=Subcellular location is not affected by light or dark conditions. {ECO:0000250\|UniProtKB:P43081}.
Tissue specificity:		Detected in the retina (PubMed:7520254). Detected in rod and cone photoreceptor cells (at protein level) (PubMed:8626484, PubMed:9620085). Also present in certain pinealocytes (PubMed:10821676). {ECO:0000269\|PubMed:10821676, ECO:0000269\|PubMed:7520254, ECO:0000269\|PubMed:8626484, ECO:0000269\|PubMed:9620085}.
Domain:		Binds three calcium ions (via EF-hands 2, 3 and 4) when calcium levels are high. Binds Mg(2+) when calcium levels are low. {ECO:0000269\|PubMed:26703466}.