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PDBsum entry 2n25
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DNA binding protein
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PDB id
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2n25
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References listed in PDB file
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Key reference
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Title
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Solution structure of the 13th c2h2 zinc finger of miz-1.
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Authors
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C.Tremblay,
M.Bédard,
M.A.Bonin,
P.Lavigne.
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Ref.
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Biochem Biophys Res Commun, 2016,
473,
471-475.
[DOI no: ]
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PubMed id
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Abstract
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Miz-1 is a BTB/POZ transcription factor that contains 13C2H2 Zinc Finger domains
(ZF). Miz-1 transactivates and represses the transcription of a myriad of genes
involved in many aspects of the biology of the cell. The detailed molecular
interactions through which Miz-1 controls transcription, including its specific
DNA binding via its ZF domains, remain to be understood and documented. In our
effort to shed light into the structural biology of Miz-1, we have undertaken
the determination of the structure of all its ZF and the characterization of
their interactions with cognate DNA. The structure of ZF 1 to 10 have already
been solved and characterized. Here, we present the structure of the synthetic
Miz-1 ZF13 determined by 2D (1)H-(1)H NMR.
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