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PDBsum entry 2mvp
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Hydrolase(aspartic proteinase)
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PDB id
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2mvp
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References listed in PDB file
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Key reference
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Title
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Structural studies of the retroviral proteinase from avian myeloblastosis associated virus.
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Authors
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D.H.Ohlendorf,
S.I.Foundling,
J.J.Wendoloski,
J.Sedlacek,
P.Strop,
F.R.Salemme.
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Ref.
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Proteins, 1992,
14,
382-391.
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PubMed id
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Note In the PDB file this reference is
annotated as "TO BE PUBLISHED".
The citation details given above were identified by an automated
search of PubMed on title and author
names, giving a
perfect match.
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Abstract
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The structure of the retroviral proteinase from avian myeloblastosis associated
virus (MAV) has been determined and refined at 2.2 A resolution. This structure
is compared with those of homologous proteinases from Rous sarcoma virus (RSV)
and human immunodeficiency type 1 virus (HIV). Through comparison with the
structure of a proteinase-inhibitor complex from HIV, a model of a complex
between MAV proteinase and a peptide substrate has been generated. Examination
of this model suggests structural basis for the diverse specifications of viral
proteinases.
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