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PDBsum entry 2mqi
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protein links
Transferase PDB id
2mqi

 

 

 

 

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JSmol PyMol  
Contents
Protein chain
100 a.a.
PDB id:
2mqi
Name: Transferase
Title: Human fyn sh2 free state
Structure: Tyrosine-protein kinase fyn. Chain: a. Fragment: unp residues 149-248. Synonym: proto-oncogene syn, proto-oncogenE C-fyn, src-like kinase, slk, p59-fyn. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: de3.
NMR struc: 20 models
Authors: R.Huculeci,L.Buts,T.Lenaerts,N.Vannuland
Key ref: R.Huculeci et al. (2016). Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity. Structure, 24, 1947-1959. PubMed id: 27692963 DOI: 10.1016/j.str.2016.08.016
Date:
20-Jun-14     Release date:   29-Jul-15    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P06241  (FYN_HUMAN) -  Tyrosine-protein kinase Fyn from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		537 a.a.
100 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.10.2  - non-specific protein-tyrosine kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
L-tyrosyl-[protein]
 + ATP
 = O-phospho-L-tyrosyl-[protein]
 + ADP
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    Added reference    
 
 
DOI no: 10.1016/j.str.2016.08.016 Structure 24:1947-1959 (2016)
PubMed id: 27692963  
 
 
Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity.
R.Huculeci, E.Cilia, A.Lyczek, L.Buts, K.Houben, M.A.Seeliger, N.van Nuland, T.Lenaerts.
 
  ABSTRACT  
 
No abstract given.

 

 

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