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UniProt functional annotation for P17497 | ||
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| UniProt code: P17497. |
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| Organism: | |
Bitis arietans (African puff adder). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Viperinae; Bitis. |
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| Function: | |
Inhibits fibrinogen interaction with platelets. Acts by binding to alpha-IIb/beta-3 (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor and collagen. {ECO:0000269|PubMed:2600082}. |
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| Subunit: | |
Monomer. {ECO:0000269|PubMed:2600082}. |
| Subcellular location: | |
Secreted {ECO:0000269|PubMed:2600082}. |
| Tissue specificity: | |
Expressed by the venom gland. {ECO:0000305|PubMed:2600082}. |
| Ptm: | |
Exists in 3 forms in the venom. The forms A, B, and C are present at 53%, 32% and 15%. The forms A and B differ by their disulfide bond pattern in the N-terminal part. No information is known about form C. {ECO:0000269|PubMed:25363287}. |
| Miscellaneous: | |
The disintegrin belongs to the long disintegrin subfamily. |
| Similarity: | |
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIa sub-subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.