UniProt functional annotation for P15498



	UniProt functional annotation for P15498

UniProt code: P15498.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

Subunit: Interacts with SHB (PubMed:12084069). Interacts with SH2B2, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK (PubMed:12393632, PubMed:12400014, PubMed:15558030). Interacts with SIAH2; without leading to its degradation (PubMed:10207103). Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion (PubMed:9697839). Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity (PubMed:9399639). May interact with CCPG1. Interacts with CLNK. Interacts with THEMIS2 (By similarity). Interacts with NEK3 and this interaction is prolactin- dependent (PubMed:15618286). Interacts with ITK (PubMed:15661896). Interacts with PTK2B/PYK2 (By similarity). Interacts with HCK. Interacts with PTK2B/PYK2 (PubMed:19207108). Interacts (via SH2 domain) with SYK (PubMed:8986718). Interacts with ANKRD54. Interacts with CD6 (By similarity). Interacts with isoform 2 of CRACR2A (PubMed:27016526). {ECO:0000250|UniProtKB:P27870, ECO:0000269|PubMed:10207103, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12393632, ECO:0000269|PubMed:12400014, ECO:0000269|PubMed:15558030, ECO:0000269|PubMed:15618286, ECO:0000269|PubMed:15661896, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:27016526, ECO:0000269|PubMed:8986718, ECO:0000269|PubMed:9399639, ECO:0000269|PubMed:9697839}.

Tissue specificity: Widely expressed in hematopoietic cells but not in other cell types.

Domain: The DH domain is involved in interaction with CCPG1. {ECO:0000250}.

Ptm: Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS) (By similarity). Phosphorylated by FYN. {ECO:0000250, ECO:0000269|PubMed:11005864}.

Miscellaneous: 'Vav' stands for the sixth letter of the Hebrew alphabet.

Sequence caution: Sequence=BAG62721.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA34383.1; Type=Frameshift; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.


Subunit:		Interacts with SHB (PubMed:12084069). Interacts with SH2B2, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK (PubMed:12393632, PubMed:12400014, PubMed:15558030). Interacts with SIAH2; without leading to its degradation (PubMed:10207103). Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion (PubMed:9697839). Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity (PubMed:9399639). May interact with CCPG1. Interacts with CLNK. Interacts with THEMIS2 (By similarity). Interacts with NEK3 and this interaction is prolactin- dependent (PubMed:15618286). Interacts with ITK (PubMed:15661896). Interacts with PTK2B/PYK2 (By similarity). Interacts with HCK. Interacts with PTK2B/PYK2 (PubMed:19207108). Interacts (via SH2 domain) with SYK (PubMed:8986718). Interacts with ANKRD54. Interacts with CD6 (By similarity). Interacts with isoform 2 of CRACR2A (PubMed:27016526). {ECO:0000250\|UniProtKB:P27870, ECO:0000269\|PubMed:10207103, ECO:0000269\|PubMed:12084069, ECO:0000269\|PubMed:12393632, ECO:0000269\|PubMed:12400014, ECO:0000269\|PubMed:15558030, ECO:0000269\|PubMed:15618286, ECO:0000269\|PubMed:15661896, ECO:0000269\|PubMed:19207108, ECO:0000269\|PubMed:27016526, ECO:0000269\|PubMed:8986718, ECO:0000269\|PubMed:9399639, ECO:0000269\|PubMed:9697839}.
Tissue specificity:		Widely expressed in hematopoietic cells but not in other cell types.
Domain:		The DH domain is involved in interaction with CCPG1. {ECO:0000250}.
Ptm:		Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS) (By similarity). Phosphorylated by FYN. {ECO:0000250, ECO:0000269\|PubMed:11005864}.
Miscellaneous:		'Vav' stands for the sixth letter of the Hebrew alphabet.
Sequence caution:		Sequence=BAG62721.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA34383.1; Type=Frameshift; Evidence={ECO:0000305};