UniProt functional annotation for Q8VHC5



	UniProt functional annotation for Q8VHC5

UniProt code: Q8VHC5.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages. {ECO:0000269|PubMed:15452577, ECO:0000269|PubMed:16249514, ECO:0000269|PubMed:17050707, ECO:0000269|PubMed:17947313}.

Subunit: Interacts with CACNA1F and CACNA1D (via IQ domain) in a calcium independent manner. Interacts (via N-terminus) with UNC119. {ECO:0000269|PubMed:15452577, ECO:0000269|PubMed:17050707, ECO:0000269|PubMed:17947313, ECO:0000269|PubMed:18296658}.

Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P57796}. Cell junction, synapse, presynapse {ECO:0000269|PubMed:15452577}. Note=Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors. {ECO:0000269|PubMed:15452577}.

Tissue specificity: Expressed in retina and in the inner hair cells (IHC) of the cochlea. {ECO:0000269|PubMed:15452577, ECO:0000269|PubMed:16249514, ECO:0000269|PubMed:17050707, ECO:0000269|PubMed:17947313}.

Ptm: Phosphorylated. Phosphorylation levels change with the light conditions and regulate the activity, but has no effect on calcium binding. {ECO:0000269|PubMed:18003854}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages. {ECO:0000269\|PubMed:15452577, ECO:0000269\|PubMed:16249514, ECO:0000269\|PubMed:17050707, ECO:0000269\|PubMed:17947313}.


Subunit:		Interacts with CACNA1F and CACNA1D (via IQ domain) in a calcium independent manner. Interacts (via N-terminus) with UNC119. {ECO:0000269\|PubMed:15452577, ECO:0000269\|PubMed:17050707, ECO:0000269\|PubMed:17947313, ECO:0000269\|PubMed:18296658}.
Subcellular location:		Cytoplasm {ECO:0000250\|UniProtKB:P57796}. Cell junction, synapse, presynapse {ECO:0000269\|PubMed:15452577}. Note=Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors. {ECO:0000269\|PubMed:15452577}.
Tissue specificity:		Expressed in retina and in the inner hair cells (IHC) of the cochlea. {ECO:0000269\|PubMed:15452577, ECO:0000269\|PubMed:16249514, ECO:0000269\|PubMed:17050707, ECO:0000269\|PubMed:17947313}.
Ptm:		Phosphorylated. Phosphorylation levels change with the light conditions and regulate the activity, but has no effect on calcium binding. {ECO:0000269\|PubMed:18003854}.