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UniProt functional annotation for G3C324 | ||
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| UniProt code: G3C324. |
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| Organism: | |
Human immunodeficiency virus 1. |
| Taxonomy: | |
Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus. |
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| Function: | |
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells. These pre- mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts). This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs. {ECO:0000256|RuleBase:RU364044}. |
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| Subunit: | |
Homomultimer; when bound to the RRE. Multimeric assembly is essential for activity. {ECO:0000256|RuleBase:RU364044}. |
| Subcellular location: | |
Host cytoplasm {ECO:0000256|RuleBase:RU364044}. Host nucleus, host nucleolus {ECO:0000256|ARBA:ARBA00004307, ECO:0000256|RuleBase:RU364044}. |
Annotations taken from UniProtKB at the EBI.