UniProt functional annotation for Q8BUR4



	UniProt functional annotation for Q8BUR4

UniProt code: Q8BUR4.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. {ECO:0000250|UniProtKB:Q14185}.

Subunit: Interacts with the SH3 domains of CRK and NCK2 via multiple sites. Interacts with nucleotide-free RAC1 via its DOCKER domain. Interacts with ELMO1, ELMO2 and probably ELMO3 via its SH3 domain. Interacts with RAC1 (By similarity). Interacts with ELMO1 and ADGRB1 (PubMed:17960134). Identified in a complex with AUTS2 and ELMO2 (PubMed:25533347). {ECO:0000250|UniProtKB:Q14185, ECO:0000269|PubMed:17960134, ECO:0000269|PubMed:25533347}.

Subcellular location: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate. {ECO:0000250}.

Domain: The DOCKER domain is necessary and sufficient for the GEF activity.

Similarity: Belongs to the DOCK family. {ECO:0000255|PROSITE- ProRule:PRU00983}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. {ECO:0000250\|UniProtKB:Q14185}.


Subunit:		Interacts with the SH3 domains of CRK and NCK2 via multiple sites. Interacts with nucleotide-free RAC1 via its DOCKER domain. Interacts with ELMO1, ELMO2 and probably ELMO3 via its SH3 domain. Interacts with RAC1 (By similarity). Interacts with ELMO1 and ADGRB1 (PubMed:17960134). Identified in a complex with AUTS2 and ELMO2 (PubMed:25533347). {ECO:0000250\|UniProtKB:Q14185, ECO:0000269\|PubMed:17960134, ECO:0000269\|PubMed:25533347}.
Subcellular location:		Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate. {ECO:0000250}.
Domain:		The DOCKER domain is necessary and sufficient for the GEF activity.
Similarity:		Belongs to the DOCK family. {ECO:0000255\|PROSITE- ProRule:PRU00983}.