UniProt functional annotation for Q9XWS0



	UniProt functional annotation for Q9XWS0

UniProt code: Q9XWS0.

Organism: Caenorhabditis elegans.

Taxonomy: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.

Function: Component of the ska-1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (By similarity). The ska-1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (By similarity). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (By similarity). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). In the complex, it mediates the interaction with microtubules (PubMed:23085020). {ECO:0000250|UniProtKB:Q96BD8, ECO:0000269|PubMed:23085020}.

Subunit: Component of the ska-1 complex, composed of two copies of ska- 1 and a single copy of ska-3. The core complex associates with microtubules and may form dimeric assemblies. Interacts with ska-3 and microtubules. {ECO:0000269|PubMed:23085020}.

Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23085020}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:23085020}.

Similarity: Belongs to the SKA1 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Caenorhabditis elegans.
Taxonomy:		Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.



Function:		Component of the ska-1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (By similarity). The ska-1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (By similarity). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (By similarity). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). In the complex, it mediates the interaction with microtubules (PubMed:23085020). {ECO:0000250\|UniProtKB:Q96BD8, ECO:0000269\|PubMed:23085020}.


Subunit:		Component of the ska-1 complex, composed of two copies of ska- 1 and a single copy of ska-3. The core complex associates with microtubules and may form dimeric assemblies. Interacts with ska-3 and microtubules. {ECO:0000269\|PubMed:23085020}.
Subcellular location:		Cytoplasm, cytoskeleton, spindle {ECO:0000269\|PubMed:23085020}. Chromosome, centromere, kinetochore {ECO:0000269\|PubMed:23085020}.
Similarity:		Belongs to the SKA1 family. {ECO:0000305}.