 |
PDBsum entry 2lu1
|
|
|
|
References listed in PDB file
|
 |
|
Key reference
|
|
|
Title
|
|
Solution nmr structure of a sheddase inhibitor prodomain from the malarial parasite plasmodium falciparum.
|
|
|
Authors
|
|
Y.He,
Y.Chen,
N.Oganesyan,
B.Ruan,
D.O'Brochta,
P.N.Bryan,
J.Orban.
|
|
|
Ref.
|
|
Proteins, 2012,
80,
2810-2817.
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
Plasmodium subtilisin 2 (Sub2) is a multidomain protein that plays an important
role in malaria infection. Here, we describe the solution NMR structure of a
conserved region of the inhibitory prodomain of Sub2 from Plasmodium falciparum,
termed prosub2. Despite the absence of any detectable sequence homology, the
protozoan prosub2 has structural similarity to bacterial and mammalian
subtilisin-like prodomains. Comparison with the three-dimensional structures of
these other prodomains suggests a likely binding interface with the catalytic
domain of Sub2 and provides insights into the locations of primary and secondary
processing sites in Plasmodium prodomains. Proteins 2012;. © 2012 Wiley
Periodicals, Inc.
|
|
|
|
|
|
|
