PDBsum entry 2lmj

Transferase

PDB id: 2lmj

Contents

Protein chain

66 a.a.

PDB id:

2lmj

Name:

Transferase

Title:

Itk-sh3

Structure:

Tyrosine-protein kinase itk/tsk. Chain: a. Fragment: sh3 domain residues 171-231. Synonym: interleukin-2-inducible t cell kinase, il-2-inducible t cell kinase, kinase emt, t-cell-specific kinase, tyrosine-protein kinase lyk. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: escherichia coli. Expression_system_taxid: 511693.

NMR struc:

20 models

Authors:

P.Kristiansen,T.Bie Andersen,Z.Huszenicza,A.H.Andreotti,A.Spurkland

Key ref:

T.Bie andersen et al. The sh3 domains of the tec family kinase itk and the family kinase lck compete for adjacent sites on t-Cel specific adapter protein. To be published, .

Date:

05-Dec-11 Release date: 05-Dec-12

Protein chain

Q08881  (ITK_HUMAN) -  Tyrosine-protein kinase ITK/TSK from Homo sapiens

Seq: 620 a.a.

Struc: 66 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site