PDBsum entry 2ll6

Oxidoreductase

PDB id: 2ll6

Contents

Protein chains

148 a.a.

17 a.a.

PDB id:

2ll6

Name:

Oxidoreductase

Title:

Solution nmr structure of cam bound to inos cam binding domain peptide

Structure:

Calmodulin. Chain: a. Synonym: cam. Engineered: yes. Nitric oxide synthase, inducible. Chain: b. Fragment: calmodulin-binding region residues 515-531. Synonym: hepatocyte nos, hep-nos, inducible no synthase, inducible nos, inos, nos type ii, peptidyl-cysteine s-nitrosylase nos2.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: calm1, calm, cam, cam1, calm2, cam2, camb, calm3, calml2, cam3, camc, camiii. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: nos2, nos2a.

NMR struc:

20 models

Authors:

M.Piazza,K.Futrega,D.E.Spratt,T.Dieckmann,J.G.Guillemette

Key ref:

M.Piazza et al. (2012). Structure and dynamics of calmodulin (CaM) bound to nitric oxide synthase peptides: effects of a phosphomimetic CaM mutation. Biochemistry, 51, 3651-3661. PubMed id: 22486744

Date:

29-Oct-11 Release date: 16-May-12

Protein chain

P0DP23  (CALM1_HUMAN) -  Calmodulin-1 from Homo sapiens

Seq: 149 a.a.

Struc: 148 a.a.

Protein chain

P35228  (NOS2_HUMAN) -  Nitric oxide synthase, inducible from Homo sapiens

Seq: 1153 a.a.

Struc: 17 a.a.

Enzyme reactions

• Enzyme class: Chain B: E.C.1.14.13.39 - nitric-oxide synthase (NADPH).
• Reaction: 2 L-arginine + 3 NADPH + 4 O2 + H⁺ = 2 L-citrulline + 2 nitric oxide + 3 NADP⁺ + 4 H2O

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Biochemistry 51:3651-3661 (2012)

PubMed id: 22486744

Structure and dynamics of calmodulin (CaM) bound to nitric oxide synthase peptides: effects of a phosphomimetic CaM mutation.

M.Piazza, K.Futrega, D.E.Spratt, T.Dieckmann, J.G.Guillemette.

ABSTRACT

No abstract given.