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UniProt functional annotation for P15257 | ||
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| UniProt code: P15257. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'- GTTAATNATTAAC-3' (By similarity). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity). {ECO:0000250|UniProtKB:P22361}. |
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| Subunit: | |
Binds DNA as a dimer (PubMed:8491173). Heterotetramer with PCBD1; formed by a dimer of dimers (By similarity). Interacts with PCBD1 (By similarity). Interacts with BHLHE41 (By similarity). {ECO:0000250|UniProtKB:P20823, ECO:0000250|UniProtKB:P22361, ECO:0000269|PubMed:8491173}. |
| Subcellular location: | |
Nucleus. |
| Tissue specificity: | |
Liver. |
| Similarity: | |
Belongs to the HNF1 homeobox family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=CAA37387.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.